FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2023170053> ?p ?o ?g. }

• W2023170053 endingPage "494012" @default.
• W2023170053 startingPage "494012" @default.
• W2023170053 abstract "A novel pH-responsive poly(amino acid) grafted with oligocation was prepared through the combination of ring-opening polymerization (ROP) and subsequent atom transfer radical polymerization (ATRP). Firstly, poly(γ-2-chloroethyl-L-glutamate) (PCELG) with a pendent 2-chloroethyl group was synthesized through ROP of γ-2-chloroethyl-L-glutamate N-carboxyanhydride (CELG NCA) using n-hexylamine as the initiator. Then, PCELG was used to initiate the ARTP of 2-aminoethyl methacrylate hydrochloride (AMA), yielding poly(L-glutamate)-graft-oligo(2-aminoethyl methacrylate hydrochloride) (PLG-g-OAMA). The pKa of PLG-g-OAMA was 7.3 established by the acid–base titration method. The amphiphilic poly(amino acid) could directly self-assemble into a vesicle in PBS. The vesicle was characterized by TEM and DLS. Hydrophilic DOX·HCl was loaded into the hollow core of the vesicle. The in vitro release behavior of DOX·HCl from the vesicle in PBS could be adjusted by the solution pH. In vitro cell experiments revealed that the vesicle could reduce the toxicity of the DOX·HCl. In addition, the preliminary gel retardation assay displayed that PLG-g-OAMA could efficiently bind DNA at a PLG-g-OAMA/DNA weight ratio of 0.3 or above, indicating its potential use as a gene carrier. More in-depth studies of the PLG-g-OAMA vesicle for drug and gene co-delivery in vitro and in vivo are in progress." @default.
• W2023170053 created "2016-06-24" @default.
• W2023170053 creator A5011786598 @default.
• W2023170053 creator A5040542464 @default.
• W2023170053 creator A5041077252 @default.
• W2023170053 creator A5045930233 @default.
• W2023170053 creator A5064591982 @default.
• W2023170053 creator A5078531761 @default.
• W2023170053 creator A5089270930 @default.
• W2023170053 date "2011-11-21" @default.
• W2023170053 modified "2023-10-12" @default.
• W2023170053 title "Facile preparation of a cationic poly(amino acid) vesicle for potential drug and gene co-delivery" @default.
• W2023170053 cites W1963526834 @default.
• W2023170053 cites W1967366094 @default.
• W2023170053 cites W1971712783 @default.
• W2023170053 cites W1973757734 @default.
• W2023170053 cites W1975639265 @default.
• W2023170053 cites W1976915573 @default.
• W2023170053 cites W1977984201 @default.
• W2023170053 cites W1979463458 @default.
• W2023170053 cites W1983785810 @default.
• W2023170053 cites W2002730188 @default.
• W2023170053 cites W2002876237 @default.
• W2023170053 cites W2006990153 @default.
• W2023170053 cites W2013311947 @default.
• W2023170053 cites W2017185308 @default.
• W2023170053 cites W2019515149 @default.
• W2023170053 cites W2029987677 @default.
• W2023170053 cites W2030498396 @default.
• W2023170053 cites W2032517146 @default.
• W2023170053 cites W2035021059 @default.
• W2023170053 cites W2037685491 @default.
• W2023170053 cites W2047732005 @default.
• W2023170053 cites W2057848113 @default.
• W2023170053 cites W2061945143 @default.
• W2023170053 cites W2075924474 @default.
• W2023170053 cites W2077808374 @default.
• W2023170053 cites W2083914702 @default.
• W2023170053 cites W2085725723 @default.
• W2023170053 cites W2089414548 @default.
• W2023170053 cites W2092139560 @default.
• W2023170053 cites W2101669760 @default.
• W2023170053 cites W2118374257 @default.
• W2023170053 cites W2121011186 @default.
• W2023170053 cites W2121781418 @default.
• W2023170053 cites W2142197470 @default.
• W2023170053 cites W2156749469 @default.
• W2023170053 cites W2167861457 @default.
• W2023170053 cites W2316985967 @default.
• W2023170053 cites W2321816604 @default.
• W2023170053 doi "https://doi.org/10.1088/0957-4484/22/49/494012" @default.
• W2023170053 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22101683" @default.
• W2023170053 hasPublicationYear "2011" @default.
• W2023170053 type Work @default.
• W2023170053 sameAs 2023170053 @default.
• W2023170053 citedByCount "61" @default.
• W2023170053 countsByYear W20231700532012 @default.
• W2023170053 countsByYear W20231700532013 @default.
• W2023170053 countsByYear W20231700532014 @default.
• W2023170053 countsByYear W20231700532015 @default.
• W2023170053 countsByYear W20231700532016 @default.
• W2023170053 countsByYear W20231700532017 @default.
• W2023170053 countsByYear W20231700532018 @default.
• W2023170053 countsByYear W20231700532019 @default.
• W2023170053 countsByYear W20231700532020 @default.
• W2023170053 countsByYear W20231700532021 @default.
• W2023170053 countsByYear W20231700532022 @default.
• W2023170053 countsByYear W20231700532023 @default.
• W2023170053 crossrefType "journal-article" @default.
• W2023170053 hasAuthorship W2023170053A5011786598 @default.
• W2023170053 hasAuthorship W2023170053A5040542464 @default.
• W2023170053 hasAuthorship W2023170053A5041077252 @default.
• W2023170053 hasAuthorship W2023170053A5045930233 @default.
• W2023170053 hasAuthorship W2023170053A5064591982 @default.
• W2023170053 hasAuthorship W2023170053A5078531761 @default.
• W2023170053 hasAuthorship W2023170053A5089270930 @default.
• W2023170053 hasConcept C104317684 @default.
• W2023170053 hasConcept C111599444 @default.
• W2023170053 hasConcept C130316041 @default.
• W2023170053 hasConcept C135983454 @default.
• W2023170053 hasConcept C13965031 @default.
• W2023170053 hasConcept C150539798 @default.
• W2023170053 hasConcept C15920480 @default.
• W2023170053 hasConcept C178790620 @default.
• W2023170053 hasConcept C183882617 @default.
• W2023170053 hasConcept C185592680 @default.
• W2023170053 hasConcept C188027245 @default.
• W2023170053 hasConcept C192562407 @default.
• W2023170053 hasConcept C202751555 @default.
• W2023170053 hasConcept C2776460385 @default.
• W2023170053 hasConcept C41625074 @default.
• W2023170053 hasConcept C44228677 @default.
• W2023170053 hasConcept C521977710 @default.
• W2023170053 hasConcept C55493867 @default.
• W2023170053 hasConcept C67407626 @default.
• W2023170053 hasConceptScore W2023170053C104317684 @default.
• W2023170053 hasConceptScore W2023170053C111599444 @default.
• W2023170053 hasConceptScore W2023170053C130316041 @default.

• next