Matches in SemOpenAlex for { <https://semopenalex.org/work/W2023170820> ?p ?o ?g. }
- W2023170820 endingPage "199" @default.
- W2023170820 startingPage "189" @default.
- W2023170820 abstract "Here off-target binding implies the binding of a small molecule of therapeutic interest to a protein target other than the primary target for which it was intended. Increasingly such off-targeting appears to be the norm rather than the exception, rational drug design notwithstanding, and can lead to detrimental side-effects, or opportunities to reposition a therapeutic agent to treat a different condition. Not surprisingly, there is significant interest in determining a priori what off-targets exist on a proteome-wide scale. Beyond determining putative off-targets is the need to understand the impact of such binding on the complete biological system, with the ultimate goal of being able to predict the phenotypic outcome. While a very ambitious goal, some progress is being made." @default.
- W2023170820 created "2016-06-24" @default.
- W2023170820 creator A5051041953 @default.
- W2023170820 creator A5066245750 @default.
- W2023170820 creator A5075833022 @default.
- W2023170820 date "2011-04-01" @default.
- W2023170820 modified "2023-10-17" @default.
- W2023170820 title "Structure-based systems biology for analyzing off-target binding" @default.
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