FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2023171655> ?p ?o ?g. }

• W2023171655 endingPage "73" @default.
• W2023171655 startingPage "53" @default.
• W2023171655 abstract "To investigate whether BM-573 (N-tert-butyl-N′-[2-(4′-methylphenylamino)-5-nitro-benzenesulfonyl]urea), an original combined thromboxane A2 synthase inhibitor and receptor antagonist, prevents reperfusion injury in acutely ischemic pigs. Twelve animals were randomly divided in two groups: a control group (n = 6) intravenously infused with vehicle, and a BM-573-treated group (n = 6) infused with BM-573 (10 mg kg−1 h−1). In both groups, the left anterior descending (LAD) coronary artery was occluded for 60 min and reperfused for 240 min. Either vehicle or BM-573 was infused 30 min before LAD occlusion and throughout the experiment. Platelet aggregation induced by arachidonic acid ex vivo measured was prevented by BM-573. In both groups, LAD occlusion decreased cardiac output, ejection fraction, slope of stroke work—end-diastolic volume relationship, and induced end-systolic pressure–volume relationship (ESPVR) rightward shift, while left ventricular afterload increased. Ventriculo-arterial coupling and mechanical efficiency decreased. In both groups, reperfusion further decreased cardiac output and ejection fraction, while ESPVR displayed a further rightward shift. Ventriculo-arterial coupling and mechanical efficiency remained impaired. Area at risk, evidenced with Evans blue, was 33.2 ± 3.4% of the LV mass (LVM) in both groups, and mean infarct size, revealed by triphenyltetrazolium chloride (TTC), was 27.3 ± 2.6% of the LVM in the BM-573-treated group (NS). Histological examination and immunohistochemical identification of desmin revealed necrosis in the anteroseptal region similar in both groups, while myocardial ATP dosages and electron microscopy also showed that BM-573 had no cardioprotective effect. These data suggest that BM-573 failed to prevent reperfusion injury in acutely ischemic pigs." @default.
• W2023171655 created "2016-06-24" @default.
• W2023171655 creator A5001454349 @default.
• W2023171655 creator A5002007905 @default.
• W2023171655 creator A5009804227 @default.
• W2023171655 creator A5020685154 @default.
• W2023171655 creator A5036457394 @default.
• W2023171655 creator A5041424887 @default.
• W2023171655 creator A5048147288 @default.
• W2023171655 creator A5068548214 @default.
• W2023171655 creator A5070075671 @default.
• W2023171655 creator A5081430054 @default.
• W2023171655 creator A5082090154 @default.
• W2023171655 creator A5084045526 @default.
• W2023171655 date "2006-03-01" @default.
• W2023171655 modified "2023-09-26" @default.
• W2023171655 title "Evaluation of BM-573, a novel TXA2 synthase inhibitor and receptor antagonist, in a porcine model of myocardial ischemia-reperfusion" @default.
• W2023171655 cites W1548990295 @default.
• W2023171655 cites W1596397105 @default.
• W2023171655 cites W169448260 @default.
• W2023171655 cites W1900819653 @default.
• W2023171655 cites W1964523691 @default.
• W2023171655 cites W1965677970 @default.
• W2023171655 cites W1985682506 @default.
• W2023171655 cites W1991117742 @default.
• W2023171655 cites W1998271889 @default.
• W2023171655 cites W1999414879 @default.
• W2023171655 cites W2005026980 @default.
• W2023171655 cites W2005519513 @default.
• W2023171655 cites W2009223871 @default.
• W2023171655 cites W2009619694 @default.
• W2023171655 cites W2022330306 @default.
• W2023171655 cites W2030939387 @default.
• W2023171655 cites W2033327514 @default.
• W2023171655 cites W2036152319 @default.
• W2023171655 cites W2036809637 @default.
• W2023171655 cites W2046419819 @default.
• W2023171655 cites W2050572185 @default.
• W2023171655 cites W2054822530 @default.
• W2023171655 cites W2060414481 @default.
• W2023171655 cites W2061938033 @default.
• W2023171655 cites W2069813488 @default.
• W2023171655 cites W2074012710 @default.
• W2023171655 cites W2074337679 @default.
• W2023171655 cites W2078199847 @default.
• W2023171655 cites W2082551574 @default.
• W2023171655 cites W2085311196 @default.
• W2023171655 cites W2086928528 @default.
• W2023171655 cites W2087991602 @default.
• W2023171655 cites W2089680713 @default.
• W2023171655 cites W2093494462 @default.
• W2023171655 cites W2097364562 @default.
• W2023171655 cites W2115227153 @default.
• W2023171655 cites W2128335734 @default.
• W2023171655 cites W2146972322 @default.
• W2023171655 cites W2147370191 @default.
• W2023171655 cites W2152396641 @default.
• W2023171655 cites W2174496022 @default.
• W2023171655 cites W2181902079 @default.
• W2023171655 cites W2314885057 @default.
• W2023171655 cites W2319834083 @default.
• W2023171655 cites W2333920681 @default.
• W2023171655 cites W2398454509 @default.
• W2023171655 cites W2400134906 @default.
• W2023171655 cites W2411627375 @default.
• W2023171655 cites W2419423616 @default.
• W2023171655 cites W2971244461 @default.
• W2023171655 cites W2320577816 @default.
• W2023171655 doi "https://doi.org/10.1016/j.prostaglandins.2005.10.002" @default.
• W2023171655 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16516810" @default.
• W2023171655 hasPublicationYear "2006" @default.
• W2023171655 type Work @default.
• W2023171655 sameAs 2023171655 @default.
• W2023171655 citedByCount "4" @default.
• W2023171655 countsByYear W20231716552018 @default.
• W2023171655 crossrefType "journal-article" @default.
• W2023171655 hasAuthorship W2023171655A5001454349 @default.
• W2023171655 hasAuthorship W2023171655A5002007905 @default.
• W2023171655 hasAuthorship W2023171655A5009804227 @default.
• W2023171655 hasAuthorship W2023171655A5020685154 @default.
• W2023171655 hasAuthorship W2023171655A5036457394 @default.
• W2023171655 hasAuthorship W2023171655A5041424887 @default.
• W2023171655 hasAuthorship W2023171655A5048147288 @default.
• W2023171655 hasAuthorship W2023171655A5068548214 @default.
• W2023171655 hasAuthorship W2023171655A5070075671 @default.
• W2023171655 hasAuthorship W2023171655A5081430054 @default.
• W2023171655 hasAuthorship W2023171655A5082090154 @default.
• W2023171655 hasAuthorship W2023171655A5084045526 @default.
• W2023171655 hasConcept C126322002 @default.
• W2023171655 hasConcept C134018914 @default.
• W2023171655 hasConcept C164705383 @default.
• W2023171655 hasConcept C170493617 @default.
• W2023171655 hasConcept C185592680 @default.
• W2023171655 hasConcept C2777649898 @default.
• W2023171655 hasConcept C2778198053 @default.
• W2023171655 hasConcept C2781024287 @default.
• W2023171655 hasConcept C42219234 @default.
• W2023171655 hasConcept C500558357 @default.

• next