Matches in SemOpenAlex for { <https://semopenalex.org/work/W2023172454> ?p ?o ?g. }
- W2023172454 endingPage "145" @default.
- W2023172454 startingPage "139" @default.
- W2023172454 abstract "Anaesthetic agents were confirmed to play a role on the tumor angiogenesis. The effect of sevoflurane on tongue squamous cell carcinoma (TSCC) cell has not been investigated. SCC-4 cells were exposed to sevoflurane after simulating hypoxia. Then, both the mRNA and protein level of hypoxia-inducible factor (HIF)-1α and VEGF were detected. The methylation states of the VEGF promoter region were also assessed to reveal the underlying mechanism. Finally, the DNA methyltransferase inhibitor 5-aza-2'-deoxycytidine (5-Aza) was administrated to reveal the relationship of DNA methylation on the regulation of the VEGF level. Results showed that sevoflurane attenuated the hypoxia-induced VEGF level without altering the HIF-1α after exposure for 24 and 72 h. Sevoflurane increased the DNA methylation of the VEGF promoter region. The attenuation effect of sevoflurane on hypoxia-induced VEGF level could be blocked by 5-Aza. We concluded that sevoflurane attenuates hypoxia-induced VEGF level via DNA methylation of the promoter region in TSCC cell." @default.
- W2023172454 created "2016-06-24" @default.
- W2023172454 creator A5011378633 @default.
- W2023172454 creator A5019560312 @default.
- W2023172454 creator A5029598771 @default.
- W2023172454 creator A5037677450 @default.
- W2023172454 creator A5040081599 @default.
- W2023172454 creator A5052412073 @default.
- W2023172454 creator A5052833788 @default.
- W2023172454 creator A5059884833 @default.
- W2023172454 creator A5070183551 @default.
- W2023172454 date "2015-04-01" @default.
- W2023172454 modified "2023-09-25" @default.
- W2023172454 title "Sevoflurane attenuate hypoxia-induced VEGF level in tongue squamous cell carcinoma cell by upregulating the DNA methylation states of the promoter region" @default.
- W2023172454 cites W1504303645 @default.
- W2023172454 cites W1587947784 @default.
- W2023172454 cites W1964375059 @default.
- W2023172454 cites W1971353320 @default.
- W2023172454 cites W1978069724 @default.
- W2023172454 cites W1991463736 @default.
- W2023172454 cites W1996781360 @default.
- W2023172454 cites W2000075161 @default.
- W2023172454 cites W2002996450 @default.
- W2023172454 cites W2005327582 @default.
- W2023172454 cites W2005410295 @default.
- W2023172454 cites W2009174204 @default.
- W2023172454 cites W2027200362 @default.
- W2023172454 cites W2032463692 @default.
- W2023172454 cites W2043732191 @default.
- W2023172454 cites W2045019299 @default.
- W2023172454 cites W2046217395 @default.
- W2023172454 cites W2048041327 @default.
- W2023172454 cites W2048285544 @default.
- W2023172454 cites W2056341285 @default.
- W2023172454 cites W2060646721 @default.
- W2023172454 cites W2069532023 @default.
- W2023172454 cites W2070216704 @default.
- W2023172454 cites W2097411259 @default.
- W2023172454 cites W2097901917 @default.
- W2023172454 cites W2102841397 @default.
- W2023172454 cites W2109492293 @default.
- W2023172454 cites W2116620228 @default.
- W2023172454 cites W2116695460 @default.
- W2023172454 cites W2125257427 @default.
- W2023172454 cites W2137823306 @default.
- W2023172454 cites W2142233318 @default.
- W2023172454 cites W2144787357 @default.
- W2023172454 cites W2155064402 @default.
- W2023172454 cites W2166069522 @default.
- W2023172454 cites W2169723660 @default.
- W2023172454 cites W4248064539 @default.
- W2023172454 doi "https://doi.org/10.1016/j.biopha.2015.02.032" @default.
- W2023172454 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25960229" @default.
- W2023172454 hasPublicationYear "2015" @default.
- W2023172454 type Work @default.
- W2023172454 sameAs 2023172454 @default.
- W2023172454 citedByCount "17" @default.
- W2023172454 countsByYear W20231724542016 @default.
- W2023172454 countsByYear W20231724542017 @default.
- W2023172454 countsByYear W20231724542018 @default.
- W2023172454 countsByYear W20231724542019 @default.
- W2023172454 countsByYear W20231724542020 @default.
- W2023172454 countsByYear W20231724542021 @default.
- W2023172454 countsByYear W20231724542022 @default.
- W2023172454 crossrefType "journal-article" @default.
- W2023172454 hasAuthorship W2023172454A5011378633 @default.
- W2023172454 hasAuthorship W2023172454A5019560312 @default.
- W2023172454 hasAuthorship W2023172454A5029598771 @default.
- W2023172454 hasAuthorship W2023172454A5037677450 @default.
- W2023172454 hasAuthorship W2023172454A5040081599 @default.
- W2023172454 hasAuthorship W2023172454A5052412073 @default.
- W2023172454 hasAuthorship W2023172454A5052833788 @default.
- W2023172454 hasAuthorship W2023172454A5059884833 @default.
- W2023172454 hasAuthorship W2023172454A5070183551 @default.
- W2023172454 hasConcept C104317684 @default.
- W2023172454 hasConcept C1491633281 @default.
- W2023172454 hasConcept C150194340 @default.
- W2023172454 hasConcept C153911025 @default.
- W2023172454 hasConcept C178790620 @default.
- W2023172454 hasConcept C185592680 @default.
- W2023172454 hasConcept C190727270 @default.
- W2023172454 hasConcept C2780394083 @default.
- W2023172454 hasConcept C2781453256 @default.
- W2023172454 hasConcept C33288867 @default.
- W2023172454 hasConcept C502942594 @default.
- W2023172454 hasConcept C540031477 @default.
- W2023172454 hasConcept C552990157 @default.
- W2023172454 hasConcept C55493867 @default.
- W2023172454 hasConcept C7836513 @default.
- W2023172454 hasConcept C86803240 @default.
- W2023172454 hasConcept C98274493 @default.
- W2023172454 hasConceptScore W2023172454C104317684 @default.
- W2023172454 hasConceptScore W2023172454C1491633281 @default.
- W2023172454 hasConceptScore W2023172454C150194340 @default.
- W2023172454 hasConceptScore W2023172454C153911025 @default.
- W2023172454 hasConceptScore W2023172454C178790620 @default.
- W2023172454 hasConceptScore W2023172454C185592680 @default.
- W2023172454 hasConceptScore W2023172454C190727270 @default.