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- W2023173096 abstract "Evidence is accumulating that 7-chloro-4-[4-diethylamino-1-methylbutyl] amino quinoline (chloroquine) displays considerable stereoselectivity in its metabolism, pharmacokinetics, macromolecular interactions, and biological activity. The availability of the enantiomers has been hampered by the failure of direct methods of resolution. We now describe a successful resolution in which the atropisomeric 1,1′-binaphthyl-2,2′-diyl hydrogen phosphate is used in a 1:1 ratio to form stereoselectively the 2:1 diastereomeric salt from one enantiomer of the base, leaving the other in solution. By this means both enantiomers of chloroquine may be readily isolated. © 1993 Wiley-Liss, Inc." @default.
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- W2023173096 date "1993-01-01" @default.
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- W2023173096 title "Resolution of 7-chloro-4(4?-diethylamino-1?methylbutyl)aminoquinoline (chloroquine) into its enantiomers" @default.
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- W2023173096 doi "https://doi.org/10.1002/chir.530050315" @default.
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