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• W2023173340 endingPage "352" @default.
• W2023173340 startingPage "347" @default.
• W2023173340 abstract "Melanoma is the most important skin cancer in terms of mortality, besides developing metastasis in about a third of the patients. Interferon-alpha (IFN-α), a highly toxic cytokine, tends to be one of the most important treatments for melanoma. Much effort is being directed at obtaining less-toxic antitumoral compounds, particularly natural compounds such as flavonoids. Our aim was to study the combined treatment of metastatic lung melanoma with IFN-α and diosmin in a murine model. In this article, we report the effect of a combined treatment of IFN-α and the flavonoid, diosmin, on a murine model of metastatic B16F10 melanoma, assessed both macroscopically (counting subpleural nodules) and microscopically by image analysis (calculating three indices). IFN-α showed a dose-dependent anti-invasive and antiproliferative activity in our study, while diosmin showed an anti-invasive activity similar to the lower dose of IFN-α used. However, the most relevant result was the synergistic antiproliferative effect shown by the combination of the flavonoid and the lowest dose of IFN-α, which was similar to that produced by the highest dose of the cytokine alone." @default.
• W2023173340 created "2016-06-24" @default.
• W2023173340 creator A5008798295 @default.
• W2023173340 creator A5033392955 @default.
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• W2023173340 date "2009-06-01" @default.
• W2023173340 modified "2023-10-03" @default.
• W2023173340 title "Synergistic Effect of Diosmin and Interferon-α on Metastatic Pulmonary Melanoma" @default.
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• W2023173340 doi "https://doi.org/10.1089/cbr.2008.0565" @default.
• W2023173340 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19538057" @default.
• W2023173340 hasPublicationYear "2009" @default.
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