Matches in SemOpenAlex for { <https://semopenalex.org/work/W2023173693> ?p ?o ?g. }
- W2023173693 endingPage "e36389" @default.
- W2023173693 startingPage "e36389" @default.
- W2023173693 abstract "Hsp70/Hsp90-organizing protein (HOP) is a member of the co-chaperone family, which directly binds to chaperones to regulate their activities. The participation of HOP in cell motility and endothelial cell functions remains largely unknown. In this study, we demonstrate that HOP is critically involved in endothelial cell migration and angiogenesis. Tube formation and capillary sprouting experiments reveal that depletion of HOP expression significantly inhibits vessel formation from endothelial cells. Wound healing and transwell migration assays show that HOP is important for endothelial cell migration. By examination of centrosome reorientation and membrane ruffle dynamics, we find that HOP plays a crucial role in the establishment of cell polarity in response to migratory stimulus. Furthermore, our data show that HOP interacts with tubulin and colocalizes with microtubules in endothelial cells. These findings indicate HOP as a novel regulator of angiogenesis that functions through promoting vascular endothelial cell polarization and migration." @default.
- W2023173693 created "2016-06-24" @default.
- W2023173693 creator A5017353282 @default.
- W2023173693 creator A5022169204 @default.
- W2023173693 creator A5036400535 @default.
- W2023173693 creator A5037989560 @default.
- W2023173693 creator A5038385200 @default.
- W2023173693 creator A5058127847 @default.
- W2023173693 creator A5065615188 @default.
- W2023173693 date "2012-04-30" @default.
- W2023173693 modified "2023-10-02" @default.
- W2023173693 title "Regulation of Vascular Endothelial Cell Polarization and Migration by Hsp70/Hsp90-Organizing Protein" @default.
- W2023173693 cites W1495947324 @default.
- W2023173693 cites W1515344935 @default.
- W2023173693 cites W1583926224 @default.
- W2023173693 cites W1811531272 @default.
- W2023173693 cites W1902219868 @default.
- W2023173693 cites W1955276614 @default.
- W2023173693 cites W1970101659 @default.
- W2023173693 cites W1978139448 @default.
- W2023173693 cites W1979346765 @default.
- W2023173693 cites W1985986741 @default.
- W2023173693 cites W1987045145 @default.
- W2023173693 cites W1994840091 @default.
- W2023173693 cites W1996810856 @default.
- W2023173693 cites W1997980682 @default.
- W2023173693 cites W2012434274 @default.
- W2023173693 cites W2013346204 @default.
- W2023173693 cites W2017780677 @default.
- W2023173693 cites W2018886962 @default.
- W2023173693 cites W2025765693 @default.
- W2023173693 cites W2030725586 @default.
- W2023173693 cites W2030916076 @default.
- W2023173693 cites W2031034652 @default.
- W2023173693 cites W2040090588 @default.
- W2023173693 cites W2040679153 @default.
- W2023173693 cites W2046598379 @default.
- W2023173693 cites W2047512850 @default.
- W2023173693 cites W2050584068 @default.
- W2023173693 cites W2051984245 @default.
- W2023173693 cites W2052785715 @default.
- W2023173693 cites W2054688293 @default.
- W2023173693 cites W2057289830 @default.
- W2023173693 cites W2082463351 @default.
- W2023173693 cites W2083975622 @default.
- W2023173693 cites W2090786177 @default.
- W2023173693 cites W2094992100 @default.
- W2023173693 cites W2106890990 @default.
- W2023173693 cites W2108987359 @default.
- W2023173693 cites W2112430693 @default.
- W2023173693 cites W2114633481 @default.
- W2023173693 cites W2118509212 @default.
- W2023173693 cites W2119616506 @default.
- W2023173693 cites W2121069774 @default.
- W2023173693 cites W2127981299 @default.
- W2023173693 cites W2130464245 @default.
- W2023173693 cites W2138078973 @default.
- W2023173693 cites W2156713309 @default.
- W2023173693 cites W2312236346 @default.
- W2023173693 cites W2334737244 @default.
- W2023173693 cites W4230026896 @default.
- W2023173693 doi "https://doi.org/10.1371/journal.pone.0036389" @default.
- W2023173693 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3340350" @default.
- W2023173693 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22558459" @default.
- W2023173693 hasPublicationYear "2012" @default.
- W2023173693 type Work @default.
- W2023173693 sameAs 2023173693 @default.
- W2023173693 citedByCount "30" @default.
- W2023173693 countsByYear W20231736932012 @default.
- W2023173693 countsByYear W20231736932013 @default.
- W2023173693 countsByYear W20231736932014 @default.
- W2023173693 countsByYear W20231736932015 @default.
- W2023173693 countsByYear W20231736932016 @default.
- W2023173693 countsByYear W20231736932017 @default.
- W2023173693 countsByYear W20231736932018 @default.
- W2023173693 countsByYear W20231736932019 @default.
- W2023173693 countsByYear W20231736932020 @default.
- W2023173693 countsByYear W20231736932021 @default.
- W2023173693 countsByYear W20231736932022 @default.
- W2023173693 countsByYear W20231736932023 @default.
- W2023173693 crossrefType "journal-article" @default.
- W2023173693 hasAuthorship W2023173693A5017353282 @default.
- W2023173693 hasAuthorship W2023173693A5022169204 @default.
- W2023173693 hasAuthorship W2023173693A5036400535 @default.
- W2023173693 hasAuthorship W2023173693A5037989560 @default.
- W2023173693 hasAuthorship W2023173693A5038385200 @default.
- W2023173693 hasAuthorship W2023173693A5058127847 @default.
- W2023173693 hasAuthorship W2023173693A5065615188 @default.
- W2023173693 hasBestOaLocation W20231736931 @default.
- W2023173693 hasConcept C104317684 @default.
- W2023173693 hasConcept C10447061 @default.
- W2023173693 hasConcept C120665830 @default.
- W2023173693 hasConcept C121332964 @default.
- W2023173693 hasConcept C123012128 @default.
- W2023173693 hasConcept C137738243 @default.
- W2023173693 hasConcept C1491633281 @default.
- W2023173693 hasConcept C169822122 @default.
- W2023173693 hasConcept C202751555 @default.