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• W2023174095 startingPage "978" @default.
• W2023174095 abstract "Runx1/AML1 plays important roles in hematopoiesis, including the commitment of cells to hematopoiesis during embryonic development, and in the maintenance of hematopoietic cell populations. It is also one of the most common genes involved in chromosomal translocations related to leukemia. One such translocation is t(8;21), which fuses the Runx1 gene to the MTG8/ETO gene and generates the Runx1-MTG8 (AML1-ETO) fusion gene. Both Runx1 and MTG8 have two additional family members that are much less studied in hematopoiesis. Here we report the expression of every member of the Runx and MTG families as well as the Runx heterodimerization partner CBFβ during hematopoietic differentiation of murine embryonic stem cells. We observed substantially increased expression of Runx1, Runx2, and MTG16 during hematopoietic differentiation. Furthermore, the increase in Runx2 expression is delayed relative to Runx1 expression, suggesting their possible sequential contribution to hematopoiesis. Runx1/AML1 plays important roles in hematopoiesis, including the commitment of cells to hematopoiesis during embryonic development, and in the maintenance of hematopoietic cell populations. It is also one of the most common genes involved in chromosomal translocations related to leukemia. One such translocation is t(8;21), which fuses the Runx1 gene to the MTG8/ETO gene and generates the Runx1-MTG8 (AML1-ETO) fusion gene. Both Runx1 and MTG8 have two additional family members that are much less studied in hematopoiesis. Here we report the expression of every member of the Runx and MTG families as well as the Runx heterodimerization partner CBFβ during hematopoietic differentiation of murine embryonic stem cells. We observed substantially increased expression of Runx1, Runx2, and MTG16 during hematopoietic differentiation. Furthermore, the increase in Runx2 expression is delayed relative to Runx1 expression, suggesting their possible sequential contribution to hematopoiesis." @default.
• W2023174095 created "2016-06-24" @default.
• W2023174095 creator A5016728387 @default.
• W2023174095 creator A5047914051 @default.
• W2023174095 creator A5063469384 @default.
• W2023174095 creator A5069356015 @default.
• W2023174095 date "2007-06-01" @default.
• W2023174095 modified "2023-09-24" @default.
• W2023174095 title "Expression of AML/Runx and ETO/MTG family members during hematopoietic differentiation of embryonic stem cells" @default.
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• W2023174095 doi "https://doi.org/10.1016/j.exphem.2007.03.002" @default.
• W2023174095 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17533052" @default.
• W2023174095 hasPublicationYear "2007" @default.
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