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• W2023175087 abstract "Gangliosides (DLG) derived from a spontaneous T cell lymphoma (Dalton's lymphoma) have been shown to impair the ability of lipopolysaccharide-activated macrophages to produce nitric oxide (NO). However, the mechanism and nature of this effect is not known. In this investigation, we sought to (1) determine whether the inhibitory action of DLG on macrophages is through the modulation of inducible nitric oxide synthase (iNOS) expression and (2) identify the possible mechanisms and signal transduction events underlying the inhibitory action of DLG. Immunoblot analysis of DLG-treated macrophages showed a decrease in iNOS expression. DLG also inhibited the production of monokines interleukin-1 and tumor necrosis factor by macrophages. However, the DLG-induced inhibition was reversible in nature. Studies showed that DLG-induced inhibition of macrophage activation could be blocked by sodium orthovanadate, indicating a role of phosphatase activity in ganglioside-induced inhibition." @default.
• W2023175087 created "2016-06-24" @default.
• W2023175087 creator A5040449491 @default.
• W2023175087 creator A5087055317 @default.
• W2023175087 date "2003-02-01" @default.
• W2023175087 modified "2023-09-25" @default.
• W2023175087 title "Inhibition of macrophage nitric oxide production by gangliosides derived from a spontaneous T cell lymphoma: the involved mechanisms" @default.
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• W2023175087 doi "https://doi.org/10.1016/s1089-8603(02)00145-3" @default.
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