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• W2023175661 abstract "Single nucleotide polymorphisms (SNPs) in the proximity of the interleukin-28B (IL28B) gene can predict spontaneous resolution of hepatitis C virus (HCV) infection and response to interferon therapy. Screening for this polymorphism has become part of the standard criteria for the management of HCV-infected patients, hence the need for a rapid, cost-effective screening method. Here, we describe a rapid PCR-based test to screen for two IL28B SNPs (rs12979860 and rs8099917). We used this test to investigate IL28B polymorphism and prevalence in a cohort of French Canadian injection drug users who are part of a unique population known to have a strong genetic founder effect. This population had lower linkage disequilibrium between the two tested SNPs as compared to other cohorts (|d′| = 0.68, r = 0.59). The special genetic makeup should be considered in the management of HCV-infected patients within that population." @default.
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• W2023175661 date "2013-03-03" @default.
• W2023175661 modified "2023-09-30" @default.
• W2023175661 title "IL28B SNP screening and distribution in the French Canadian population using a rapid PCR-based test" @default.
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• W2023175661 doi "https://doi.org/10.1007/s00251-013-0688-7" @default.
• W2023175661 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4713959" @default.
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