FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2023176529> ?p ?o ?g. }

• W2023176529 endingPage "2784" @default.
• W2023176529 startingPage "2780" @default.
• W2023176529 abstract "In yeast, the mRNA encoded by the MAT alpha 1 gene is unstable (t1/2 = 5 min) and the mRNAs encoded by the ACT1 gene (t1/2 = 30 min) and the PGK1 gene (t1/2 = 45 min) are stable. To understand the RNA structural features that dictate mRNA decay rates in yeast, we have constructed PGK1/MAT alpha 1 and ACT1/MAT alpha 1 gene fusions and analyzed the decay rates of the resultant chimeric transcripts. Fusion of a MAT alpha 1 segment containing 73% of the coding region and the 3' untranslated region to either of the stable genes is sufficient to cause rapid decay of the chimeric mRNAs (t1/2 = 6-7.5 min). Sequences required for this rapid decay are not found in the MAT alpha 1 3' untranslated region but are located within a 42-nucleotide segment of the coding region that has a high content (8 out of 14) of rare codons. Introduction of a translational stop codon upstream of this region stabilizes the hybrid mRNAs, indicating that the rapid decay promoted by these sequences is dependent on ribosomal translocation." @default.
• W2023176529 created "2016-06-24" @default.
• W2023176529 creator A5014796446 @default.
• W2023176529 creator A5052124121 @default.
• W2023176529 date "1990-04-01" @default.
• W2023176529 modified "2023-10-03" @default.
• W2023176529 title "Translation and a 42-nucleotide segment within the coding region of the mRNA encoded by the MAT alpha 1 gene are involved in promoting rapid mRNA decay in yeast." @default.
• W2023176529 cites W1504552716 @default.
• W2023176529 cites W1580464233 @default.
• W2023176529 cites W1758946369 @default.
• W2023176529 cites W1790510139 @default.
• W2023176529 cites W1790958488 @default.
• W2023176529 cites W1799375255 @default.
• W2023176529 cites W1831176116 @default.
• W2023176529 cites W1938794721 @default.
• W2023176529 cites W1971724293 @default.
• W2023176529 cites W1973592220 @default.
• W2023176529 cites W1973782344 @default.
• W2023176529 cites W1983658304 @default.
• W2023176529 cites W1999066229 @default.
• W2023176529 cites W1999347013 @default.
• W2023176529 cites W2001748566 @default.
• W2023176529 cites W2004382481 @default.
• W2023176529 cites W2005115290 @default.
• W2023176529 cites W2007346514 @default.
• W2023176529 cites W2014669590 @default.
• W2023176529 cites W2029399500 @default.
• W2023176529 cites W2029817683 @default.
• W2023176529 cites W2035270583 @default.
• W2023176529 cites W2038019779 @default.
• W2023176529 cites W2046291479 @default.
• W2023176529 cites W2047711915 @default.
• W2023176529 cites W2047855213 @default.
• W2023176529 cites W2048227952 @default.
• W2023176529 cites W2050183043 @default.
• W2023176529 cites W2064639895 @default.
• W2023176529 cites W2077077811 @default.
• W2023176529 cites W2080532845 @default.
• W2023176529 cites W2081090611 @default.
• W2023176529 cites W2090772541 @default.
• W2023176529 cites W2116945838 @default.
• W2023176529 cites W2138270253 @default.
• W2023176529 doi "https://doi.org/10.1073/pnas.87.7.2780" @default.
• W2023176529 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/53774" @default.
• W2023176529 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/2181450" @default.
• W2023176529 hasPublicationYear "1990" @default.
• W2023176529 type Work @default.
• W2023176529 sameAs 2023176529 @default.
• W2023176529 citedByCount "130" @default.
• W2023176529 countsByYear W20231765292013 @default.
• W2023176529 countsByYear W20231765292015 @default.
• W2023176529 countsByYear W20231765292016 @default.
• W2023176529 countsByYear W20231765292017 @default.
• W2023176529 countsByYear W20231765292021 @default.
• W2023176529 crossrefType "journal-article" @default.
• W2023176529 hasAuthorship W2023176529A5014796446 @default.
• W2023176529 hasAuthorship W2023176529A5052124121 @default.
• W2023176529 hasBestOaLocation W20231765292 @default.
• W2023176529 hasConcept C104317684 @default.
• W2023176529 hasConcept C105580179 @default.
• W2023176529 hasConcept C12464233 @default.
• W2023176529 hasConcept C149364088 @default.
• W2023176529 hasConcept C150194340 @default.
• W2023176529 hasConcept C153911025 @default.
• W2023176529 hasConcept C26260077 @default.
• W2023176529 hasConcept C512185932 @default.
• W2023176529 hasConcept C54355233 @default.
• W2023176529 hasConcept C86803240 @default.
• W2023176529 hasConcept C89604277 @default.
• W2023176529 hasConcept C91779695 @default.
• W2023176529 hasConceptScore W2023176529C104317684 @default.
• W2023176529 hasConceptScore W2023176529C105580179 @default.
• W2023176529 hasConceptScore W2023176529C12464233 @default.
• W2023176529 hasConceptScore W2023176529C149364088 @default.
• W2023176529 hasConceptScore W2023176529C150194340 @default.
• W2023176529 hasConceptScore W2023176529C153911025 @default.
• W2023176529 hasConceptScore W2023176529C26260077 @default.
• W2023176529 hasConceptScore W2023176529C512185932 @default.
• W2023176529 hasConceptScore W2023176529C54355233 @default.
• W2023176529 hasConceptScore W2023176529C86803240 @default.
• W2023176529 hasConceptScore W2023176529C89604277 @default.
• W2023176529 hasConceptScore W2023176529C91779695 @default.
• W2023176529 hasIssue "7" @default.
• W2023176529 hasLocation W20231765291 @default.
• W2023176529 hasLocation W20231765292 @default.
• W2023176529 hasLocation W20231765293 @default.
• W2023176529 hasLocation W20231765294 @default.
• W2023176529 hasLocation W20231765295 @default.
• W2023176529 hasOpenAccess W2023176529 @default.
• W2023176529 hasPrimaryLocation W20231765291 @default.
• W2023176529 hasRelatedWork W1501969175 @default.
• W2023176529 hasRelatedWork W1587255170 @default.
• W2023176529 hasRelatedWork W1995194063 @default.
• W2023176529 hasRelatedWork W2005416777 @default.
• W2023176529 hasRelatedWork W2056605242 @default.
• W2023176529 hasRelatedWork W2100021388 @default.
• W2023176529 hasRelatedWork W2100859474 @default.
• W2023176529 hasRelatedWork W2114859361 @default.

• next