FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2023176714> ?p ?o ?g. }

• W2023176714 endingPage "53" @default.
• W2023176714 startingPage "53" @default.
• W2023176714 abstract "Colesevelam hydrochloride is a synthetic, nonsystemically absorbed polymer that functions as a bile acid sequestrant for the treatment of hypercholesterolemia. Recently, colesevelam was investigated for the treatment of heterozygous familial hypercholesterolemia (HeFH) in the pediatric/adolescent population aged 10-17 years.The purpose of this article is to review the disease state of HeFH in children and adolescents, review the pharmacologic mechanism of action, kinetics, and safety profile of colesevelam, analyze the results of a recent clinical trial of colesevelam in the pediatric/adolescent HeFH population, and discuss the role of colesevelam as a viable treatment option for HeFH.A literature search using Medline (1966-03 May 2010), PubMed (1950-03 May 2010), Science Direct (1994-03 May 2010), and International Pharmaceutical Abstracts (2004-2010) was performed using the search term colesevelam. English language, original research, and review articles were examined, and citations from these articles were also assessed. The manufacturer's prescribing information and the Food and Drug Administration review of the new drug application for the powder formulation were also examined.A 32-week trial was performed investigating the efficacy of colesevelam as monotherapy or combination therapy with a stable statin regimen. Upon completion of the trial, significant benefits were found in regard to the treatment of HeFH and the lowering of low-density lipoprotein cholesterol, total cholesterol, and other secondary measures. Safety and tolerability were also examined throughout the duration of the clinical trial, with adverse drug reactions considered mild in severity.Colesevelam has been shown to reduce low-density lipoprotein cholesterol levels significantly in pediatric/adolescent patients with HeFH, while maintaining a mild side effect profile. Although further research would be beneficial for long-term effects in this population, colesevelam should be considered when developing a treatment regimen for HeFH in the pediatric/adolescent population." @default.
• W2023176714 created "2016-06-24" @default.
• W2023176714 creator A5011930317 @default.
• W2023176714 creator A5018592073 @default.
• W2023176714 creator A5085814651 @default.
• W2023176714 creator A5087170338 @default.
• W2023176714 date "2010-08-01" @default.
• W2023176714 modified "2023-10-14" @default.
• W2023176714 title "Role of colesevelam in managing heterozygous familial hypercholesterolemia in adolescents and children" @default.
• W2023176714 cites W1722038924 @default.
• W2023176714 cites W1924484409 @default.
• W2023176714 cites W1970849884 @default.
• W2023176714 cites W1977447015 @default.
• W2023176714 cites W1990831940 @default.
• W2023176714 cites W1999798165 @default.
• W2023176714 cites W2011511504 @default.
• W2023176714 cites W2014207518 @default.
• W2023176714 cites W2024151426 @default.
• W2023176714 cites W2034781327 @default.
• W2023176714 cites W2036523512 @default.
• W2023176714 cites W2048083630 @default.
• W2023176714 cites W2056306713 @default.
• W2023176714 cites W2068930396 @default.
• W2023176714 cites W2071802081 @default.
• W2023176714 cites W2073374742 @default.
• W2023176714 cites W2082891861 @default.
• W2023176714 cites W2085737093 @default.
• W2023176714 cites W2112534505 @default.
• W2023176714 cites W2133448117 @default.
• W2023176714 cites W2133591735 @default.
• W2023176714 cites W2137781481 @default.
• W2023176714 cites W2139353545 @default.
• W2023176714 cites W2151779725 @default.
• W2023176714 cites W2153196496 @default.
• W2023176714 cites W2158706207 @default.
• W2023176714 cites W2166830703 @default.
• W2023176714 cites W2315613231 @default.
• W2023176714 cites W2336250349 @default.
• W2023176714 cites W2418764982 @default.
• W2023176714 cites W3148954605 @default.
• W2023176714 doi "https://doi.org/10.2147/ahmt.s9272" @default.
• W2023176714 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3915789" @default.
• W2023176714 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24600261" @default.
• W2023176714 hasPublicationYear "2010" @default.
• W2023176714 type Work @default.
• W2023176714 sameAs 2023176714 @default.
• W2023176714 citedByCount "8" @default.
• W2023176714 countsByYear W20231767142015 @default.
• W2023176714 countsByYear W20231767142018 @default.
• W2023176714 countsByYear W20231767142019 @default.
• W2023176714 countsByYear W20231767142021 @default.
• W2023176714 crossrefType "journal-article" @default.
• W2023176714 hasAuthorship W2023176714A5011930317 @default.
• W2023176714 hasAuthorship W2023176714A5018592073 @default.
• W2023176714 hasAuthorship W2023176714A5085814651 @default.
• W2023176714 hasAuthorship W2023176714A5087170338 @default.
• W2023176714 hasBestOaLocation W20231767141 @default.
• W2023176714 hasConcept C126322002 @default.
• W2023176714 hasConcept C197934379 @default.
• W2023176714 hasConcept C2778163477 @default.
• W2023176714 hasConcept C2778375690 @default.
• W2023176714 hasConcept C2778657065 @default.
• W2023176714 hasConcept C2781413609 @default.
• W2023176714 hasConcept C2908647359 @default.
• W2023176714 hasConcept C535046627 @default.
• W2023176714 hasConcept C71924100 @default.
• W2023176714 hasConcept C98274493 @default.
• W2023176714 hasConcept C99454951 @default.
• W2023176714 hasConceptScore W2023176714C126322002 @default.
• W2023176714 hasConceptScore W2023176714C197934379 @default.
• W2023176714 hasConceptScore W2023176714C2778163477 @default.
• W2023176714 hasConceptScore W2023176714C2778375690 @default.
• W2023176714 hasConceptScore W2023176714C2778657065 @default.
• W2023176714 hasConceptScore W2023176714C2781413609 @default.
• W2023176714 hasConceptScore W2023176714C2908647359 @default.
• W2023176714 hasConceptScore W2023176714C535046627 @default.
• W2023176714 hasConceptScore W2023176714C71924100 @default.
• W2023176714 hasConceptScore W2023176714C98274493 @default.
• W2023176714 hasConceptScore W2023176714C99454951 @default.
• W2023176714 hasLocation W20231767141 @default.
• W2023176714 hasLocation W20231767142 @default.
• W2023176714 hasLocation W20231767143 @default.
• W2023176714 hasLocation W20231767144 @default.
• W2023176714 hasOpenAccess W2023176714 @default.
• W2023176714 hasPrimaryLocation W20231767141 @default.
• W2023176714 hasRelatedWork W1968036257 @default.
• W2023176714 hasRelatedWork W1975683799 @default.
• W2023176714 hasRelatedWork W2007986200 @default.
• W2023176714 hasRelatedWork W2020073008 @default.
• W2023176714 hasRelatedWork W2034336678 @default.
• W2023176714 hasRelatedWork W2107697672 @default.
• W2023176714 hasRelatedWork W2142988574 @default.
• W2023176714 hasRelatedWork W2171389860 @default.
• W2023176714 hasRelatedWork W2281121233 @default.
• W2023176714 hasRelatedWork W2186247562 @default.
• W2023176714 isParatext "false" @default.
• W2023176714 isRetracted "false" @default.
• W2023176714 magId "2023176714" @default.

• next