FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2023176823> ?p ?o ?g. }

• W2023176823 endingPage "106" @default.
• W2023176823 startingPage "101" @default.
• W2023176823 abstract "The alkaloid rich extracts from an acid/base extraction of bulb material of Haemanthus coccineus L., H. montanus Baker and H. sanguineus Jacq. revealed that two montanine type Amaryllidaceae alkaloids, montanine (1) and coccinine (2) were the major alkaloid constituents. Together these two alkaloids constituted 88, 91 and 98% of the total alkaloid extract from each species respectively. GC–MS analysis revealed that H. coccineus and H. sanguineus had a relative abundance of coccinine (74 and 91% respectively) to montanine (14 and 7% respectively); whereas H. montanus had 20% coccinine and 71% montanine. The three extracts and two isolated alkaloids were evaluated for binding to the serotonin transporter protein (SERT) in vitro. Affinity to SERT was highest in H. coccineus (IC50 = 2.0 ± 1.1 μg/ml) followed by H. montanus (IC50 = 6.8 ± 1.0 μg/ml) and H. sanguineus (IC50 = 28.7 ± 1.1 μg/ml). Montanine (IC50 = 121.3 ± 3.6 μM or 36.56 ± 1.14 μg/ml; Ki = 66.01 μM) was more active than coccinine (IC50 = 196.3 ± 3.8 μM or 59.15 ± 1.08 μg/ml; Ki = 106.8 μM), both of which were less active than the total alkaloid extracts of each species investigated. The possible synergistic effects of two coccinine/montanine mixtures (80:20 and 20:80) were investigated, however the mixtures gave similar activities as the pure compounds and did not show any increase in activity or activity similar to the total alkaloid extracts. Thus the considerably higher activity observed in the total alkaloid extracts is not correlated to the relative proportions of coccinine and montanine in the extracts and thus are likely to be due to more potent unidentified minor constituents. Both alkaloids exhibited low binding affinity to P-glycoprotein (P-gp) as demonstrated by low inhibition of calcein-AM efflux in the MDCK-MDR1 cell line. This indicates that P-gp efflux will not be limiting for blood–brain-barrier passage of the alkaloids." @default.
• W2023176823 created "2016-06-24" @default.
• W2023176823 creator A5009560029 @default.
• W2023176823 creator A5010232216 @default.
• W2023176823 creator A5016599557 @default.
• W2023176823 creator A5044156865 @default.
• W2023176823 creator A5047371538 @default.
• W2023176823 creator A5052724558 @default.
• W2023176823 creator A5080512325 @default.
• W2023176823 date "2013-09-01" @default.
• W2023176823 modified "2023-09-27" @default.
• W2023176823 title "Serotonin transporter protein (SERT) and P-glycoprotein (P-gp) binding activity of montanine and coccinine from three species of Haemanthus L. (Amaryllidaceae)" @default.
• W2023176823 cites W1958334384 @default.
• W2023176823 cites W1973544766 @default.
• W2023176823 cites W1974367106 @default.
• W2023176823 cites W1979830235 @default.
• W2023176823 cites W1982261968 @default.
• W2023176823 cites W1984107082 @default.
• W2023176823 cites W1990136506 @default.
• W2023176823 cites W1996929853 @default.
• W2023176823 cites W2012752314 @default.
• W2023176823 cites W2019939591 @default.
• W2023176823 cites W2020439107 @default.
• W2023176823 cites W2024763593 @default.
• W2023176823 cites W2038059465 @default.
• W2023176823 cites W2041342222 @default.
• W2023176823 cites W2043160969 @default.
• W2023176823 cites W2044255919 @default.
• W2023176823 cites W2047998678 @default.
• W2023176823 cites W2056777568 @default.
• W2023176823 cites W2060969194 @default.
• W2023176823 cites W2076832620 @default.
• W2023176823 cites W2324104248 @default.
• W2023176823 cites W4249475620 @default.
• W2023176823 cites W584838941 @default.
• W2023176823 doi "https://doi.org/10.1016/j.sajb.2013.06.002" @default.
• W2023176823 hasPublicationYear "2013" @default.
• W2023176823 type Work @default.
• W2023176823 sameAs 2023176823 @default.
• W2023176823 citedByCount "9" @default.
• W2023176823 countsByYear W20231768232015 @default.
• W2023176823 countsByYear W20231768232016 @default.
• W2023176823 countsByYear W20231768232019 @default.
• W2023176823 countsByYear W20231768232020 @default.
• W2023176823 countsByYear W20231768232021 @default.
• W2023176823 countsByYear W20231768232022 @default.
• W2023176823 crossrefType "journal-article" @default.
• W2023176823 hasAuthorship W2023176823A5009560029 @default.
• W2023176823 hasAuthorship W2023176823A5010232216 @default.
• W2023176823 hasAuthorship W2023176823A5016599557 @default.
• W2023176823 hasAuthorship W2023176823A5044156865 @default.
• W2023176823 hasAuthorship W2023176823A5047371538 @default.
• W2023176823 hasAuthorship W2023176823A5052724558 @default.
• W2023176823 hasAuthorship W2023176823A5080512325 @default.
• W2023176823 hasBestOaLocation W20231768231 @default.
• W2023176823 hasConcept C120228162 @default.
• W2023176823 hasConcept C185592680 @default.
• W2023176823 hasConcept C202751555 @default.
• W2023176823 hasConcept C2777667214 @default.
• W2023176823 hasConcept C2777752497 @default.
• W2023176823 hasConcept C2778105851 @default.
• W2023176823 hasConcept C2778218060 @default.
• W2023176823 hasConcept C55493867 @default.
• W2023176823 hasConcept C59822182 @default.
• W2023176823 hasConcept C71240020 @default.
• W2023176823 hasConcept C86803240 @default.
• W2023176823 hasConceptScore W2023176823C120228162 @default.
• W2023176823 hasConceptScore W2023176823C185592680 @default.
• W2023176823 hasConceptScore W2023176823C202751555 @default.
• W2023176823 hasConceptScore W2023176823C2777667214 @default.
• W2023176823 hasConceptScore W2023176823C2777752497 @default.
• W2023176823 hasConceptScore W2023176823C2778105851 @default.
• W2023176823 hasConceptScore W2023176823C2778218060 @default.
• W2023176823 hasConceptScore W2023176823C55493867 @default.
• W2023176823 hasConceptScore W2023176823C59822182 @default.
• W2023176823 hasConceptScore W2023176823C71240020 @default.
• W2023176823 hasConceptScore W2023176823C86803240 @default.
• W2023176823 hasLocation W20231768231 @default.
• W2023176823 hasLocation W20231768232 @default.
• W2023176823 hasOpenAccess W2023176823 @default.
• W2023176823 hasPrimaryLocation W20231768231 @default.
• W2023176823 hasRelatedWork W2154813271 @default.
• W2023176823 hasRelatedWork W221357174 @default.
• W2023176823 hasRelatedWork W2274811202 @default.
• W2023176823 hasRelatedWork W2737591899 @default.
• W2023176823 hasRelatedWork W2811128561 @default.
• W2023176823 hasRelatedWork W2917878437 @default.
• W2023176823 hasRelatedWork W2965938265 @default.
• W2023176823 hasRelatedWork W3087652199 @default.
• W2023176823 hasRelatedWork W3091905952 @default.
• W2023176823 hasRelatedWork W3134329053 @default.
• W2023176823 hasVolume "88" @default.
• W2023176823 isParatext "false" @default.
• W2023176823 isRetracted "false" @default.
• W2023176823 magId "2023176823" @default.
• W2023176823 workType "article" @default.