Matches in SemOpenAlex for { <https://semopenalex.org/work/W2023177078> ?p ?o ?g. }
- W2023177078 endingPage "107" @default.
- W2023177078 startingPage "100" @default.
- W2023177078 abstract "Background and Objectives Microsatellite instability (MSI) has been documented in a subset of sporadic tumors. Loss of heterozygosity (LOH) on chromosome 11 loci in breast cancer is a frequent event. The purpose of the present study is to examine the incidence of microsatellite alterations in in situ and invasive human breast carcinoma and to clarify their significance in regulating the dynamics of cancer progression. Methods Four highly polymorphic (CA)n repeat microsatellites were used to determine microsatellite alterations in ten ductal carcinoma in situ (DCIS) and 19 invasive ductal carcinoma (IDC). To investigate the expression of p53, ER (estrogen receptor), and PR (progesterone receptor) association with MSI, immunohistochemistry staining was applied. Results MSI were detected in 20% (2/10) of DCIS and in 47.4% (9/19) of IDC. The frequency of MSI in IDC was significantly higher than that in DCIS (P <0.001). Also, the MSI seemed to correlate with clinical stage (P = 0.0001) and tumor size (P = 0.004) but not histological grade or age. In addition, we found that 27% of the tumors showed LOH at 11q23.3-24 region between loci D11S934 and D11S912. Seven of nine MSI cases demonstrated low or no expression of p53. However, there was significantly reduced expression of PR, but not ER in MSI cases. Conclusions Our results suggest that breast cancer acquires the RER phenotype (replication-error phenotype) in the relatively late stages, and that the RER phenotype is associated with aggressiveness of IDC (infiltrative duct carcinoma). The result also implicated that mismatch repair failure can alter the expression of PR but not ER and p53. J. Surg. Oncol. 2000;74:100–107. © 2000 Wiley-Liss, Inc." @default.
- W2023177078 created "2016-06-24" @default.
- W2023177078 creator A5021898832 @default.
- W2023177078 creator A5027310614 @default.
- W2023177078 creator A5061974988 @default.
- W2023177078 creator A5066150223 @default.
- W2023177078 creator A5070543258 @default.
- W2023177078 creator A5084758259 @default.
- W2023177078 creator A5087662823 @default.
- W2023177078 date "2000-01-01" @default.
- W2023177078 modified "2023-09-26" @default.
- W2023177078 title "Microsatellite alterations on human chromosome 11 in in situ and invasive breast cancer: A microdissection microsatellite analysis and correlation with p53, ER (estrogen receptor), and PR (progesterone receptor) protein immunoreactivity" @default.
- W2023177078 cites W1493525469 @default.
- W2023177078 cites W1969846119 @default.
- W2023177078 cites W1973693817 @default.
- W2023177078 cites W1995819860 @default.
- W2023177078 cites W2010871781 @default.
- W2023177078 cites W2020643740 @default.
- W2023177078 cites W2027278954 @default.
- W2023177078 cites W2027830190 @default.
- W2023177078 cites W2035801462 @default.
- W2023177078 cites W2044643325 @default.
- W2023177078 cites W2046883067 @default.
- W2023177078 cites W2053355503 @default.
- W2023177078 cites W2060937867 @default.
- W2023177078 cites W2080952568 @default.
- W2023177078 cites W2082255272 @default.
- W2023177078 cites W2088098884 @default.
- W2023177078 cites W2088316555 @default.
- W2023177078 cites W2090119773 @default.
- W2023177078 cites W2090383712 @default.
- W2023177078 cites W2091670521 @default.
- W2023177078 cites W2142659575 @default.
- W2023177078 cites W2157603620 @default.
- W2023177078 doi "https://doi.org/10.1002/1096-9098(200006)74:2<100::aid-jso5>3.0.co;2-o" @default.
- W2023177078 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10914818" @default.
- W2023177078 hasPublicationYear "2000" @default.
- W2023177078 type Work @default.
- W2023177078 sameAs 2023177078 @default.
- W2023177078 citedByCount "21" @default.
- W2023177078 countsByYear W20231770782013 @default.
- W2023177078 crossrefType "journal-article" @default.
- W2023177078 hasAuthorship W2023177078A5021898832 @default.
- W2023177078 hasAuthorship W2023177078A5027310614 @default.
- W2023177078 hasAuthorship W2023177078A5061974988 @default.
- W2023177078 hasAuthorship W2023177078A5066150223 @default.
- W2023177078 hasAuthorship W2023177078A5070543258 @default.
- W2023177078 hasAuthorship W2023177078A5084758259 @default.
- W2023177078 hasAuthorship W2023177078A5087662823 @default.
- W2023177078 hasConcept C104317684 @default.
- W2023177078 hasConcept C11242284 @default.
- W2023177078 hasConcept C121608353 @default.
- W2023177078 hasConcept C126322002 @default.
- W2023177078 hasConcept C142724271 @default.
- W2023177078 hasConcept C143589142 @default.
- W2023177078 hasConcept C180754005 @default.
- W2023177078 hasConcept C204232928 @default.
- W2023177078 hasConcept C2777546739 @default.
- W2023177078 hasConcept C2779767149 @default.
- W2023177078 hasConcept C2780862961 @default.
- W2023177078 hasConcept C502942594 @default.
- W2023177078 hasConcept C530470458 @default.
- W2023177078 hasConcept C54355233 @default.
- W2023177078 hasConcept C61320498 @default.
- W2023177078 hasConcept C71924100 @default.
- W2023177078 hasConcept C84606932 @default.
- W2023177078 hasConcept C86803240 @default.
- W2023177078 hasConcept C98717036 @default.
- W2023177078 hasConceptScore W2023177078C104317684 @default.
- W2023177078 hasConceptScore W2023177078C11242284 @default.
- W2023177078 hasConceptScore W2023177078C121608353 @default.
- W2023177078 hasConceptScore W2023177078C126322002 @default.
- W2023177078 hasConceptScore W2023177078C142724271 @default.
- W2023177078 hasConceptScore W2023177078C143589142 @default.
- W2023177078 hasConceptScore W2023177078C180754005 @default.
- W2023177078 hasConceptScore W2023177078C204232928 @default.
- W2023177078 hasConceptScore W2023177078C2777546739 @default.
- W2023177078 hasConceptScore W2023177078C2779767149 @default.
- W2023177078 hasConceptScore W2023177078C2780862961 @default.
- W2023177078 hasConceptScore W2023177078C502942594 @default.
- W2023177078 hasConceptScore W2023177078C530470458 @default.
- W2023177078 hasConceptScore W2023177078C54355233 @default.
- W2023177078 hasConceptScore W2023177078C61320498 @default.
- W2023177078 hasConceptScore W2023177078C71924100 @default.
- W2023177078 hasConceptScore W2023177078C84606932 @default.
- W2023177078 hasConceptScore W2023177078C86803240 @default.
- W2023177078 hasConceptScore W2023177078C98717036 @default.
- W2023177078 hasIssue "2" @default.
- W2023177078 hasLocation W20231770781 @default.
- W2023177078 hasLocation W20231770782 @default.
- W2023177078 hasOpenAccess W2023177078 @default.
- W2023177078 hasPrimaryLocation W20231770781 @default.
- W2023177078 hasRelatedWork W1981116543 @default.
- W2023177078 hasRelatedWork W2002762645 @default.
- W2023177078 hasRelatedWork W2023177078 @default.
- W2023177078 hasRelatedWork W2159514485 @default.
- W2023177078 hasRelatedWork W2332663781 @default.
- W2023177078 hasRelatedWork W2356587536 @default.