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- W2023177828 abstract "Recently it has become clear that α2-adrenergic receptors (α2AR) functionally couple to Gs as well as Gi, thus inducing a complex modulation of adenylyl cyclase activity. It is unknown whether α2AR-Gs coupling undergoes agonist-promoted desensitization. Therefore, in CHO cells expressing the three cloned human α2AR subtypes (α2C10, α2C4, and α2C2), we assessed the ability of α2AR-mediated stimulation of adenylyl cyclase activity to undergo short-term agonist-promoted desensitization. To isolate α2AR-Gs coupling, cells were pretreated with pertussis toxin, which ablates Gi coupling. Following agonist exposure, both α2C10- and α2C2-mediated stimulation of adenylyl cyclase activity underwent marked desensitization. In distinct contrast, α2C4-mediated stimulation of adenylyl cyclase activity underwent no agonist-promoted desensitization. Thus, α2AR-Gs coupling undergoes agonist-promoted desensitization and does so in a subtype-selective manner." @default.
- W2023177828 created "2016-06-24" @default.
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- W2023177828 date "1993-05-01" @default.
- W2023177828 modified "2023-09-26" @default.
- W2023177828 title "Functional α2-Adrenergic Receptor-Gs Coupling Undergoes Agonist-Promoted Desensitization in a Subtype-Selective Manner" @default.
- W2023177828 doi "https://doi.org/10.1006/bbrc.1993.1626" @default.
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