Matches in SemOpenAlex for { <https://semopenalex.org/work/W2023177835> ?p ?o ?g. }
- W2023177835 endingPage "1158" @default.
- W2023177835 startingPage "1145" @default.
- W2023177835 abstract "Recently, the inevitable metabolic reprogramming experienced by cancer cells as a result of the onset of cellular proliferation has been added to the list of hallmarks of the cancer cell phenotype. Proliferation is bound to the synchronous fluctuation of cycles of an increased glycolysis concurrent with a restrained oxidative phosphorylation. Mitochondria are key players in the metabolic cycling experienced during proliferation because of their essential roles in the transduction of biological energy and in defining the life–death fate of the cell. These two activities are molecularly and functionally integrated and are both targets of commonly altered cancer genes. Moreover, energetic metabolism of the cancer cell also affords a target to develop new therapies because the activity of mitochondria has an unquestionable tumor suppressor function. In this review, we summarize most of these findings paying special attention to the opportunity that translation of energetic metabolism into the clinics could afford for the management of cancer patients. More specifically, we emphasize the role that mitochondrial β-F1-ATPase has as a marker for the prognosis of different cancer patients as well as in predicting the tumor response to therapy." @default.
- W2023177835 created "2016-06-24" @default.
- W2023177835 creator A5019704720 @default.
- W2023177835 creator A5030003937 @default.
- W2023177835 creator A5032754419 @default.
- W2023177835 creator A5059298518 @default.
- W2023177835 creator A5062712259 @default.
- W2023177835 creator A5071050629 @default.
- W2023177835 date "2009-12-01" @default.
- W2023177835 modified "2023-09-23" @default.
- W2023177835 title "The tumor suppressor function of mitochondria: Translation into the clinics" @default.
- W2023177835 cites W1493702629 @default.
- W2023177835 cites W1503428755 @default.
- W2023177835 cites W1503667331 @default.
- W2023177835 cites W1522763255 @default.
- W2023177835 cites W1528061714 @default.
- W2023177835 cites W1548851567 @default.
- W2023177835 cites W1559768539 @default.
- W2023177835 cites W1593737978 @default.
- W2023177835 cites W1621124914 @default.
- W2023177835 cites W1675105927 @default.
- W2023177835 cites W1751530372 @default.
- W2023177835 cites W1836071808 @default.
- W2023177835 cites W1967482096 @default.
- W2023177835 cites W1970990976 @default.
- W2023177835 cites W1971209629 @default.
- W2023177835 cites W1972910722 @default.
- W2023177835 cites W1975033372 @default.
- W2023177835 cites W1975082755 @default.
- W2023177835 cites W1975566828 @default.
- W2023177835 cites W1975609166 @default.
- W2023177835 cites W1976632546 @default.
- W2023177835 cites W1977176778 @default.
- W2023177835 cites W1978173977 @default.
- W2023177835 cites W1979389283 @default.
- W2023177835 cites W1981079102 @default.
- W2023177835 cites W1982245720 @default.
- W2023177835 cites W1986568749 @default.
- W2023177835 cites W1986599999 @default.
- W2023177835 cites W1987054795 @default.
- W2023177835 cites W1988013867 @default.
- W2023177835 cites W1988097332 @default.
- W2023177835 cites W1989040551 @default.
- W2023177835 cites W1989627660 @default.
- W2023177835 cites W1991429659 @default.
- W2023177835 cites W1992667313 @default.
- W2023177835 cites W1992783368 @default.
- W2023177835 cites W1993626201 @default.
- W2023177835 cites W1993691900 @default.
- W2023177835 cites W1994148625 @default.
- W2023177835 cites W1994318934 @default.
- W2023177835 cites W1994857926 @default.
- W2023177835 cites W1996365670 @default.
- W2023177835 cites W2001568034 @default.
- W2023177835 cites W2002311094 @default.
- W2023177835 cites W2003023964 @default.
- W2023177835 cites W2005166958 @default.
- W2023177835 cites W2005828644 @default.
- W2023177835 cites W2006294797 @default.
- W2023177835 cites W2008044691 @default.
- W2023177835 cites W2008523969 @default.
- W2023177835 cites W2011876441 @default.
- W2023177835 cites W2012733189 @default.
- W2023177835 cites W2014058353 @default.
- W2023177835 cites W2014758663 @default.
- W2023177835 cites W2014947131 @default.
- W2023177835 cites W2015207840 @default.
- W2023177835 cites W2015732113 @default.
- W2023177835 cites W2018026783 @default.
- W2023177835 cites W2025149885 @default.
- W2023177835 cites W2025673381 @default.
- W2023177835 cites W2026334721 @default.
- W2023177835 cites W2026555011 @default.
- W2023177835 cites W2027133675 @default.
- W2023177835 cites W2027442494 @default.
- W2023177835 cites W2027705428 @default.
- W2023177835 cites W2028935677 @default.
- W2023177835 cites W2029221665 @default.
- W2023177835 cites W2030025965 @default.
- W2023177835 cites W2030963645 @default.
- W2023177835 cites W2033958147 @default.
- W2023177835 cites W2034269086 @default.
- W2023177835 cites W2034279252 @default.
- W2023177835 cites W2035608099 @default.
- W2023177835 cites W2036065781 @default.
- W2023177835 cites W2036799174 @default.
- W2023177835 cites W2037021643 @default.
- W2023177835 cites W2037253045 @default.
- W2023177835 cites W2039859863 @default.
- W2023177835 cites W2040031153 @default.
- W2023177835 cites W2041883933 @default.
- W2023177835 cites W2045962235 @default.
- W2023177835 cites W2047653070 @default.
- W2023177835 cites W2049042780 @default.
- W2023177835 cites W2049462796 @default.
- W2023177835 cites W2049683923 @default.
- W2023177835 cites W2049714677 @default.
- W2023177835 cites W2052703170 @default.