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• W2023177876 abstract "In order to investigate whether strychnine-insensitive glycine sites coupled with hippocampal NMDA (N-methyl-d-aspartate) receptors are involved in spatial memory in rats, we examined the effects of intrahippocampal treatment of d-cycloserine (DCS), a glycine-site agonist, on spatial-memory deficits which were produced by an NMDA antagonist MK-801 (dizocilpine) on the radial-arm maze task. After the acquisition of this task, the radial-maze performance was tested under the combined treatments of intraperitoneal MK-801 or saline (SAL) and intrahippocampal DCS or SAL. The results showed that MK-801 impaired the performance, and that DCS improved the MK-801-induced performance impairment. These results suggest that glycine sites are involved in spatial memory through their modulatory action on hippocampal NMDA receptors." @default.
• W2023177876 created "2016-06-24" @default.
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• W2023177876 date "1998-12-01" @default.
• W2023177876 modified "2023-09-23" @default.
• W2023177876 title "Intrahippocampal d-cycloserine improves MK-801-induced memory deficits: radial-arm maze performance in rats" @default.
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• W2023177876 doi "https://doi.org/10.1016/s0006-8993(98)01043-9" @default.
• W2023177876 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9838131" @default.
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