FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2023178035> ?p ?o ?g. }

• W2023178035 endingPage "932" @default.
• W2023178035 startingPage "913" @default.
• W2023178035 abstract "Pit-1 is a tissue-specific POU domain factor obligatory for the appearance of three cell phenotypes in the anterior pituitary gland. Expression of the pit-1 gene requires the actions of a cell-specific 390-bp enhancer, located 10 kb 5' of the pit-1 transcription initiation site, within sequence that proves essential for effective pituitary targeting of transgene expression during murine development. The enhancer requires the concerted actions of a cell-specific cis-active element, Pit-1 autoregulatory sites, and atypical morphogen response elements. Pituitary ontogeny in the Pit-1-defective Snell dwarf mouse reveals that pit-1 autoregulation is not required for initial activation or continued expression during critical phases of Pit-1 target gene activation but, subsequently, is necessary for maintenance of pit-1 gene expression following birth. A potent 1,25-dihydroxyvitamin D3-responsive enhancer element defines a physiological site in which a single nucleotide alteration in the sequence of core binding motifs modulates the spacing rules for nuclear receptor response elements. Unexpectedly, the major retinoic acid response element is absolutely dependent on Pit-1 for retinoic acid receptor function. On this DNA element, Pit-1 appears to function as a coregulator of the retinoic acid receptor, suggesting an intriguing linkage between a cell-specific transcription factor and the actions of morphogen receptors that is likely to be prototypic of mechanisms by which other cell-specific transcription factors might confer morphogen receptor responsivity during mammalian organogenesis." @default.
• W2023178035 created "2016-06-24" @default.
• W2023178035 creator A5000068004 @default.
• W2023178035 creator A5006688231 @default.
• W2023178035 creator A5022198855 @default.
• W2023178035 creator A5032044745 @default.
• W2023178035 creator A5033037996 @default.
• W2023178035 creator A5046025947 @default.
• W2023178035 creator A5060964279 @default.
• W2023178035 creator A5064608982 @default.
• W2023178035 date "1993-06-01" @default.
• W2023178035 modified "2023-10-15" @default.
• W2023178035 title "A tissue-specific enhancer confers Pit-1-dependent morphogen inducibility and autoregulation on the pit-1 gene." @default.
• W2023178035 cites W1542255581 @default.
• W2023178035 cites W1559756705 @default.
• W2023178035 cites W1578055894 @default.
• W2023178035 cites W1595664534 @default.
• W2023178035 cites W1670076014 @default.
• W2023178035 cites W1964977592 @default.
• W2023178035 cites W1965735992 @default.
• W2023178035 cites W1970092656 @default.
• W2023178035 cites W1970132032 @default.
• W2023178035 cites W1971980406 @default.
• W2023178035 cites W1978286524 @default.
• W2023178035 cites W1981864913 @default.
• W2023178035 cites W1982810916 @default.
• W2023178035 cites W1984509210 @default.
• W2023178035 cites W1987040411 @default.
• W2023178035 cites W1987269203 @default.
• W2023178035 cites W1990097058 @default.
• W2023178035 cites W1992289621 @default.
• W2023178035 cites W1996223704 @default.
• W2023178035 cites W1997031612 @default.
• W2023178035 cites W1997473658 @default.
• W2023178035 cites W1997514802 @default.
• W2023178035 cites W1998108444 @default.
• W2023178035 cites W1998737642 @default.
• W2023178035 cites W2001105836 @default.
• W2023178035 cites W2007084552 @default.
• W2023178035 cites W2007510308 @default.
• W2023178035 cites W2009357627 @default.
• W2023178035 cites W2011467252 @default.
• W2023178035 cites W2012761399 @default.
• W2023178035 cites W2018314725 @default.
• W2023178035 cites W2018442116 @default.
• W2023178035 cites W2019673480 @default.
• W2023178035 cites W2029177264 @default.
• W2023178035 cites W2030904938 @default.
• W2023178035 cites W2034454625 @default.
• W2023178035 cites W2034580146 @default.
• W2023178035 cites W2037745464 @default.
• W2023178035 cites W2037861531 @default.
• W2023178035 cites W2041149796 @default.
• W2023178035 cites W2041270901 @default.
• W2023178035 cites W2041545601 @default.
• W2023178035 cites W2042243055 @default.
• W2023178035 cites W2043507832 @default.
• W2023178035 cites W2044863269 @default.
• W2023178035 cites W2052366220 @default.
• W2023178035 cites W2062617470 @default.
• W2023178035 cites W2064557280 @default.
• W2023178035 cites W2075232957 @default.
• W2023178035 cites W2076241945 @default.
• W2023178035 cites W2076497575 @default.
• W2023178035 cites W2080541298 @default.
• W2023178035 cites W2080924363 @default.
• W2023178035 cites W2081239940 @default.
• W2023178035 cites W2085124463 @default.
• W2023178035 cites W2092789129 @default.
• W2023178035 cites W2095228325 @default.
• W2023178035 cites W2097145517 @default.
• W2023178035 cites W2098793652 @default.
• W2023178035 cites W2102082802 @default.
• W2023178035 cites W2107157336 @default.
• W2023178035 cites W2112823160 @default.
• W2023178035 cites W2117825435 @default.
• W2023178035 cites W2120176836 @default.
• W2023178035 cites W2128334381 @default.
• W2023178035 cites W2138897956 @default.
• W2023178035 cites W2141343816 @default.
• W2023178035 cites W2147427274 @default.
• W2023178035 cites W2148750115 @default.
• W2023178035 cites W2152355177 @default.
• W2023178035 cites W2166815259 @default.
• W2023178035 cites W2168395432 @default.
• W2023178035 cites W2170143371 @default.
• W2023178035 cites W2171131273 @default.
• W2023178035 cites W2176697008 @default.
• W2023178035 cites W2183572982 @default.
• W2023178035 cites W4241869599 @default.
• W2023178035 cites W81844578 @default.
• W2023178035 doi "https://doi.org/10.1101/gad.7.6.913" @default.
• W2023178035 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8504933" @default.
• W2023178035 hasPublicationYear "1993" @default.
• W2023178035 type Work @default.
• W2023178035 sameAs 2023178035 @default.
• W2023178035 citedByCount "229" @default.
• W2023178035 countsByYear W20231780352012 @default.

• next