Matches in SemOpenAlex for { <https://semopenalex.org/work/W2023178268> ?p ?o ?g. }
Showing items 1 to 70 of
70
with 100 items per page.
- W2023178268 endingPage "S356" @default.
- W2023178268 startingPage "S356" @default.
- W2023178268 abstract "A third part of the world population has been exposed to the pathogen Mycobacterium tuberculosis, the etiological agent of tuberculosis (TB). TB is a deadly disease, and its treatment has been hampered because of the lack of new antibiotics or the development of new antimycobacterial agents against this pathogen. The situation is aggravated because of the appearance of multidrug-resistant strains. In Mexican traditional medicine, records showed Artemisia ludoviciana for the treatment of TB. Thus, the combination of antibiotics and plant extracts might represent new antimycobacterial agents as an attractive alternative.The biological activities of ethanol extract obtained from A. ludoviciana were evaluated for its antimycobacterial activities using an M. tuberculosis clinical isolate. Also, the toxicity of the extracts was assessed ex vivo and in vivo using the human-derived macrophages cell line (THP-1) and the Artemia spp. model, respectively. Lastly, the inflammatory response of macrophages exposed to the extracts was also evaluated.The ethanol extract of A. ludoviciana showed antimycobacterial activity with a MIC of 250 μg/mL against a clinical strain of M. tuberculosis. Ex vivo cytotoxicity using the THP-1 cell line incubated with the ethanol extract showed an IC50 of 20 μg/mL. On the other hand, the Artemia model's toxicity test showed moderate toxicity when the A. ludoviciana extract was tested with LC50 of 195.64 μg/mL. Analysis of the inflammatory response of THP-1 cells exposed to the same extract showed no increase in secreted interleukine-6 and -10. Also, no effect was observed in the pro-inflammatory tumor necrosis factor-α cytokine level. Moreover, a chemical profile of the extracts identified achillin as the major component in the ethanol extract, along with other minor components such as thujone and stigmasterol.We showed that the ethanol extract of A. ludoviciana possessed antimycobacterial activity and could potentially be used to supplement the antibiotic treatment of TB." @default.
- W2023178268 created "2016-06-24" @default.
- W2023178268 creator A5000053225 @default.
- W2023178268 creator A5024413232 @default.
- W2023178268 creator A5026246856 @default.
- W2023178268 date "2011-09-01" @default.
- W2023178268 modified "2023-09-23" @default.
- W2023178268 title "Cytotoxic potential of five Iranian medicinal plants by Artemia urmiana" @default.
- W2023178268 doi "https://doi.org/10.1016/j.clinbiochem.2011.08.896" @default.
- W2023178268 hasPublicationYear "2011" @default.
- W2023178268 type Work @default.
- W2023178268 sameAs 2023178268 @default.
- W2023178268 citedByCount "0" @default.
- W2023178268 crossrefType "journal-article" @default.
- W2023178268 hasAuthorship W2023178268A5000053225 @default.
- W2023178268 hasAuthorship W2023178268A5024413232 @default.
- W2023178268 hasAuthorship W2023178268A5026246856 @default.
- W2023178268 hasConcept C126322002 @default.
- W2023178268 hasConcept C142724271 @default.
- W2023178268 hasConcept C150903083 @default.
- W2023178268 hasConcept C207001950 @default.
- W2023178268 hasConcept C26291073 @default.
- W2023178268 hasConcept C2776460866 @default.
- W2023178268 hasConcept C2777975735 @default.
- W2023178268 hasConcept C2779685592 @default.
- W2023178268 hasConcept C2781069245 @default.
- W2023178268 hasConcept C29730261 @default.
- W2023178268 hasConcept C501593827 @default.
- W2023178268 hasConcept C556039675 @default.
- W2023178268 hasConcept C71924100 @default.
- W2023178268 hasConcept C86803240 @default.
- W2023178268 hasConcept C89423630 @default.
- W2023178268 hasConcept C98274493 @default.
- W2023178268 hasConceptScore W2023178268C126322002 @default.
- W2023178268 hasConceptScore W2023178268C142724271 @default.
- W2023178268 hasConceptScore W2023178268C150903083 @default.
- W2023178268 hasConceptScore W2023178268C207001950 @default.
- W2023178268 hasConceptScore W2023178268C26291073 @default.
- W2023178268 hasConceptScore W2023178268C2776460866 @default.
- W2023178268 hasConceptScore W2023178268C2777975735 @default.
- W2023178268 hasConceptScore W2023178268C2779685592 @default.
- W2023178268 hasConceptScore W2023178268C2781069245 @default.
- W2023178268 hasConceptScore W2023178268C29730261 @default.
- W2023178268 hasConceptScore W2023178268C501593827 @default.
- W2023178268 hasConceptScore W2023178268C556039675 @default.
- W2023178268 hasConceptScore W2023178268C71924100 @default.
- W2023178268 hasConceptScore W2023178268C86803240 @default.
- W2023178268 hasConceptScore W2023178268C89423630 @default.
- W2023178268 hasConceptScore W2023178268C98274493 @default.
- W2023178268 hasIssue "13" @default.
- W2023178268 hasLocation W20231782681 @default.
- W2023178268 hasOpenAccess W2023178268 @default.
- W2023178268 hasPrimaryLocation W20231782681 @default.
- W2023178268 hasRelatedWork W2047815418 @default.
- W2023178268 hasRelatedWork W2050953601 @default.
- W2023178268 hasRelatedWork W2084547689 @default.
- W2023178268 hasRelatedWork W2788776646 @default.
- W2023178268 hasRelatedWork W2884095943 @default.
- W2023178268 hasRelatedWork W2894690716 @default.
- W2023178268 hasRelatedWork W2968438745 @default.
- W2023178268 hasRelatedWork W3093170431 @default.
- W2023178268 hasRelatedWork W3210687582 @default.
- W2023178268 hasRelatedWork W4235616939 @default.
- W2023178268 hasVolume "44" @default.
- W2023178268 isParatext "false" @default.
- W2023178268 isRetracted "false" @default.
- W2023178268 magId "2023178268" @default.
- W2023178268 workType "article" @default.