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- W2023180301 abstract "Enhanced Fas system-mediated hepatocyte apoptosis is observed in hepatitis C virus (HCV)- and hepatitis B virus (HBV)-associated chronic liver diseases. In these forms of viral hepatitis, liver-infiltrating lymphocytes that recognize the viral antigen on hepatocytes become activated and express cytolytic Fas ligand (FasL) molecules. In contrast, hepatocytes exhibit enhanced Fas expression and become susceptible to FasL-mediated death. Augmentation of the Fas system has also been observed in other liver diseases and biliary disorders. Moreover, the Fas system is involved in removing aged hepatocytes. Thus, Fas-mediated apoptosis plays an important role in several liver diseases and in maintaining normal liver homeostasis." @default.
- W2023180301 created "2016-06-24" @default.
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- W2023180301 creator A5056628067 @default.
- W2023180301 date "1999-09-01" @default.
- W2023180301 modified "2023-09-26" @default.
- W2023180301 title "Involvement of Fas system-mediated apoptosis in pathogenesis of viral hepatitis" @default.
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- W2023180301 doi "https://doi.org/10.1046/j.1365-2893.1999.00175.x" @default.
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