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- W2023180460 abstract "Novel peptide mimetics of GDP-fucose were designed and synthesized targeting inhibitors of the fucosyltransferases that transfer l-fucose from GDP-fucose to oligosaccharides, on the basis of the background that nikkomycin Z, a peptide mimetic of UDP-N-acetylglucosamine, shows potent inhibitory activity toward an N-acetylglucosamine transfer enzyme. The synthetic routes of the GDP-fucose mimetics take advantage of an enzymatic aldol reaction catalyzed by l-threonine aldolase to prepare the guanine carrying β-hydroxy-α-l-amino acid, a key synthetic intermediate." @default.
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- W2023180460 date "2004-01-01" @default.
- W2023180460 modified "2023-09-27" @default.
- W2023180460 title "Design and Synthesis of Peptide Mimetics of GDP-Fucose: Targeting Inhibitors of Fucosyltransferases" @default.
- W2023180460 doi "https://doi.org/10.1055/s-2003-44984" @default.
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