FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2023181241> ?p ?o ?g. }

• W2023181241 endingPage "248" @default.
• W2023181241 startingPage "239" @default.
• W2023181241 abstract "BACKGROUND: Severe pouchitis and Crohn's disease-like complications are 2 adverse postoperative complications that confound the success of the IPAA in patients with ulcerative colitis. To date, approximately 83 single nucleotide polymorphisms within 55 genes have been associated with IBD. OBJECTIVE: The aim of this study was to identify single-nucleotide polymorphisms that correlate with complications after IPAA that could be utilized in a gene signature fashion to predict postoperative complications and aid in preoperative surgical decision making. DESIGN: One hundred forty-two IPAA patients were retrospectively classified as “asymptomatic” (n = 104, defined as no Crohn's disease-like complications or severe pouchitis for at least 2 years after IPAA) and compared with a “severe pouchitis” group (n = 12, ≥4 episodes pouchitis per year for 2 years including the need for long-term therapy to maintain remission) and a “Crohn's disease-like” group (n = 26, presence of fistulae, pouch inlet stricture, proximal small-bowel disease, or pouch granulomata, occurring at least 6 months after surgery). Genotyping for 83 single-nucleotide polymorphisms previously associated with Crohn's disease and/or ulcerative colitis was performed on a customized Illumina genotyping platform. The top 2 single-nucleotide polymorphisms statistically identified as being independently associated with each of Crohn's disease-like and severe pouchitis were used in a multivariate logistic regression model. These single-nucleotide polymorphisms were then used to create probability equations to predict overall chance of a positive or negative outcome for that complication. RESULTS: The top 2 single-nucleotide polymorphisms for Crohn's disease-like complications were in the 10q21 locus and the gene for PTGER4 (p = 0.006 and 0.007), whereas for severe pouchitis it was NOD2 and TNFSF15 (p = 0.003 and 0.011). Probability equations suggested that the risk of these 2 complications greatly increased with increasing number of risk alleles, going as high as 92% for severe pouchitis and 65% for Crohn's disease-like complications. CONCLUSION: In this IPAA patient cohort, mutations in the 10q21 locus and the PTGER4 gene were associated with Crohn's disease-like complications, whereas mutations in NOD2 and TNFSF15 correlated with severe pouchitis. Preoperative genetic analysis and use of such gene signatures hold promise for improved preoperative surgical patient selection to minimize these IPAA complications." @default.
• W2023181241 created "2016-06-24" @default.
• W2023181241 creator A5004253588 @default.
• W2023181241 creator A5010953549 @default.
• W2023181241 creator A5023433871 @default.
• W2023181241 creator A5023677180 @default.
• W2023181241 creator A5030640066 @default.
• W2023181241 creator A5035340822 @default.
• W2023181241 creator A5072314631 @default.
• W2023181241 creator A5073226018 @default.
• W2023181241 creator A5086634091 @default.
• W2023181241 date "2012-03-01" @default.
• W2023181241 modified "2023-10-13" @default.
• W2023181241 title "Genetic Risk Profiling and Gene Signature Modeling to Predict Risk of Complications After IPAA" @default.
• W2023181241 cites W1642457845 @default.
• W2023181241 cites W1670573097 @default.
• W2023181241 cites W1969673534 @default.
• W2023181241 cites W1969767037 @default.
• W2023181241 cites W1970723690 @default.
• W2023181241 cites W1973201714 @default.
• W2023181241 cites W1973757667 @default.
• W2023181241 cites W1975728475 @default.
• W2023181241 cites W1981972532 @default.
• W2023181241 cites W1983526913 @default.
• W2023181241 cites W1989074904 @default.
• W2023181241 cites W1999085701 @default.
• W2023181241 cites W2011197968 @default.
• W2023181241 cites W2014700549 @default.
• W2023181241 cites W2023616646 @default.
• W2023181241 cites W2028052264 @default.
• W2023181241 cites W2049655097 @default.
• W2023181241 cites W2049829682 @default.
• W2023181241 cites W2057775297 @default.
• W2023181241 cites W2059091622 @default.
• W2023181241 cites W2064027072 @default.
• W2023181241 cites W2064741210 @default.
• W2023181241 cites W2080475619 @default.
• W2023181241 cites W2080713361 @default.
• W2023181241 cites W2082328686 @default.
• W2023181241 cites W2083065071 @default.
• W2023181241 cites W2093356677 @default.
• W2023181241 cites W2096853390 @default.
• W2023181241 cites W2106048192 @default.
• W2023181241 cites W2106901334 @default.
• W2023181241 cites W2116799923 @default.
• W2023181241 cites W2117974617 @default.
• W2023181241 cites W2121308112 @default.
• W2023181241 cites W2121514846 @default.
• W2023181241 cites W2122031852 @default.
• W2023181241 cites W2134783591 @default.
• W2023181241 cites W2152532561 @default.
• W2023181241 cites W2168647393 @default.
• W2023181241 cites W4231022815 @default.
• W2023181241 doi "https://doi.org/10.1097/dcr.0b013e31823e2d18" @default.
• W2023181241 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22469789" @default.
• W2023181241 hasPublicationYear "2012" @default.
• W2023181241 type Work @default.
• W2023181241 sameAs 2023181241 @default.
• W2023181241 citedByCount "31" @default.
• W2023181241 countsByYear W20231812412013 @default.
• W2023181241 countsByYear W20231812412014 @default.
• W2023181241 countsByYear W20231812412015 @default.
• W2023181241 countsByYear W20231812412016 @default.
• W2023181241 countsByYear W20231812412017 @default.
• W2023181241 countsByYear W20231812412018 @default.
• W2023181241 countsByYear W20231812412019 @default.
• W2023181241 countsByYear W20231812412020 @default.
• W2023181241 countsByYear W20231812412022 @default.
• W2023181241 crossrefType "journal-article" @default.
• W2023181241 hasAuthorship W2023181241A5004253588 @default.
• W2023181241 hasAuthorship W2023181241A5010953549 @default.
• W2023181241 hasAuthorship W2023181241A5023433871 @default.
• W2023181241 hasAuthorship W2023181241A5023677180 @default.
• W2023181241 hasAuthorship W2023181241A5030640066 @default.
• W2023181241 hasAuthorship W2023181241A5035340822 @default.
• W2023181241 hasAuthorship W2023181241A5072314631 @default.
• W2023181241 hasAuthorship W2023181241A5073226018 @default.
• W2023181241 hasAuthorship W2023181241A5086634091 @default.
• W2023181241 hasConcept C104317684 @default.
• W2023181241 hasConcept C126322002 @default.
• W2023181241 hasConcept C135763542 @default.
• W2023181241 hasConcept C153209595 @default.
• W2023181241 hasConcept C2777910003 @default.
• W2023181241 hasConcept C2778260677 @default.
• W2023181241 hasConcept C2779134260 @default.
• W2023181241 hasConcept C2779280984 @default.
• W2023181241 hasConcept C2779454807 @default.
• W2023181241 hasConcept C2780479503 @default.
• W2023181241 hasConcept C31467283 @default.
• W2023181241 hasConcept C54355233 @default.
• W2023181241 hasConcept C71924100 @default.
• W2023181241 hasConcept C86803240 @default.
• W2023181241 hasConcept C90924648 @default.
• W2023181241 hasConceptScore W2023181241C104317684 @default.
• W2023181241 hasConceptScore W2023181241C126322002 @default.
• W2023181241 hasConceptScore W2023181241C135763542 @default.
• W2023181241 hasConceptScore W2023181241C153209595 @default.
• W2023181241 hasConceptScore W2023181241C2777910003 @default.

• next