Matches in SemOpenAlex for { <https://semopenalex.org/work/W2023181590> ?p ?o ?g. }
Showing items 1 to 99 of
99
with 100 items per page.
- W2023181590 endingPage "146" @default.
- W2023181590 startingPage "139" @default.
- W2023181590 abstract "Light and scanning electron microscopy showed that 0.25, 0.5 and 1 times the minimum inhibitory concentrations (MICs) of sulbactam (SULB) caused filament formation in different species of Enterobacteriaceae, while 2 and 4 times the MICs caused spheroplast formation and subsequent lysis. By using a competitive assay with 125I-penicillin X, SULB showed a primary affinity for the PBP 1a and PBP3 of Escherichia coli, as well as for the PBP1a of Proteus mirabilis. The bactericidal interaction of human polymorphonuclear leukocytes (PMN) and SULB against E. coli K-1 resistant to the bactericidal activity of human serum was studied in vitro; however, SULB concentrations showed variations in the medium according to human kinetic data. Under these conditions, bacterial growth occurred in Hanks balanced salt solution containing SULB, PMN, or SULB-PMN in combination. In addition, bactericidal activity was observed in serum, with a killing rate of 90% for PMN or SULB, and 95% for SULB-PMN in combination. The postantibiotic enhancement of PMN bactericidal function was assessed against E. coli K1 pretreated with 0.5 the MIC of SULB (32 μg/ml) for 0.5 hr. The 90% bacterial killing rate of PMN occurred by 1.5 hr for pretreated bacteria and by 2.5 hr for untreated bacteria. Furthermore, the luminol-enhanced chemiluminescence (CL) assay using an E. coli stimulus showed that SULB does not modify PMN activity." @default.
- W2023181590 created "2016-06-24" @default.
- W2023181590 creator A5010781665 @default.
- W2023181590 creator A5020558935 @default.
- W2023181590 creator A5022157667 @default.
- W2023181590 creator A5027952316 @default.
- W2023181590 creator A5056016198 @default.
- W2023181590 date "1989-07-01" @default.
- W2023181590 modified "2023-09-27" @default.
- W2023181590 title "Sulbactam: Secondary mechanisms of action" @default.
- W2023181590 cites W1991833505 @default.
- W2023181590 cites W1996341536 @default.
- W2023181590 cites W1999529748 @default.
- W2023181590 cites W2016742695 @default.
- W2023181590 cites W2025070614 @default.
- W2023181590 cites W2026431407 @default.
- W2023181590 cites W2037223904 @default.
- W2023181590 cites W2059829730 @default.
- W2023181590 cites W2085131725 @default.
- W2023181590 cites W2106024571 @default.
- W2023181590 cites W2330545434 @default.
- W2023181590 doi "https://doi.org/10.1016/0732-8893(89)90126-0" @default.
- W2023181590 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/2591173" @default.
- W2023181590 hasPublicationYear "1989" @default.
- W2023181590 type Work @default.
- W2023181590 sameAs 2023181590 @default.
- W2023181590 citedByCount "11" @default.
- W2023181590 countsByYear W20231815902012 @default.
- W2023181590 countsByYear W20231815902015 @default.
- W2023181590 countsByYear W20231815902019 @default.
- W2023181590 countsByYear W20231815902021 @default.
- W2023181590 crossrefType "journal-article" @default.
- W2023181590 hasAuthorship W2023181590A5010781665 @default.
- W2023181590 hasAuthorship W2023181590A5020558935 @default.
- W2023181590 hasAuthorship W2023181590A5022157667 @default.
- W2023181590 hasAuthorship W2023181590A5027952316 @default.
- W2023181590 hasAuthorship W2023181590A5056016198 @default.
- W2023181590 hasConcept C104317684 @default.
- W2023181590 hasConcept C174802600 @default.
- W2023181590 hasConcept C185592680 @default.
- W2023181590 hasConcept C202751555 @default.
- W2023181590 hasConcept C203014093 @default.
- W2023181590 hasConcept C2778039505 @default.
- W2023181590 hasConcept C2778478555 @default.
- W2023181590 hasConcept C2778910516 @default.
- W2023181590 hasConcept C2779631663 @default.
- W2023181590 hasConcept C2779902561 @default.
- W2023181590 hasConcept C501593827 @default.
- W2023181590 hasConcept C523546767 @default.
- W2023181590 hasConcept C54355233 @default.
- W2023181590 hasConcept C547475151 @default.
- W2023181590 hasConcept C55493867 @default.
- W2023181590 hasConcept C57409179 @default.
- W2023181590 hasConcept C86803240 @default.
- W2023181590 hasConcept C89423630 @default.
- W2023181590 hasConcept C94665300 @default.
- W2023181590 hasConcept C99054511 @default.
- W2023181590 hasConceptScore W2023181590C104317684 @default.
- W2023181590 hasConceptScore W2023181590C174802600 @default.
- W2023181590 hasConceptScore W2023181590C185592680 @default.
- W2023181590 hasConceptScore W2023181590C202751555 @default.
- W2023181590 hasConceptScore W2023181590C203014093 @default.
- W2023181590 hasConceptScore W2023181590C2778039505 @default.
- W2023181590 hasConceptScore W2023181590C2778478555 @default.
- W2023181590 hasConceptScore W2023181590C2778910516 @default.
- W2023181590 hasConceptScore W2023181590C2779631663 @default.
- W2023181590 hasConceptScore W2023181590C2779902561 @default.
- W2023181590 hasConceptScore W2023181590C501593827 @default.
- W2023181590 hasConceptScore W2023181590C523546767 @default.
- W2023181590 hasConceptScore W2023181590C54355233 @default.
- W2023181590 hasConceptScore W2023181590C547475151 @default.
- W2023181590 hasConceptScore W2023181590C55493867 @default.
- W2023181590 hasConceptScore W2023181590C57409179 @default.
- W2023181590 hasConceptScore W2023181590C86803240 @default.
- W2023181590 hasConceptScore W2023181590C89423630 @default.
- W2023181590 hasConceptScore W2023181590C94665300 @default.
- W2023181590 hasConceptScore W2023181590C99054511 @default.
- W2023181590 hasIssue "4" @default.
- W2023181590 hasLocation W20231815901 @default.
- W2023181590 hasLocation W20231815902 @default.
- W2023181590 hasOpenAccess W2023181590 @default.
- W2023181590 hasPrimaryLocation W20231815901 @default.
- W2023181590 hasRelatedWork W2023181590 @default.
- W2023181590 hasRelatedWork W2036347073 @default.
- W2023181590 hasRelatedWork W2061297944 @default.
- W2023181590 hasRelatedWork W2076614389 @default.
- W2023181590 hasRelatedWork W2096590918 @default.
- W2023181590 hasRelatedWork W2281198901 @default.
- W2023181590 hasRelatedWork W2315403443 @default.
- W2023181590 hasRelatedWork W3030052757 @default.
- W2023181590 hasRelatedWork W3116848248 @default.
- W2023181590 hasRelatedWork W85487054 @default.
- W2023181590 hasVolume "12" @default.
- W2023181590 isParatext "false" @default.
- W2023181590 isRetracted "false" @default.
- W2023181590 magId "2023181590" @default.
- W2023181590 workType "article" @default.