FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2023181635> ?p ?o ?g. }

• W2023181635 endingPage "733" @default.
• W2023181635 startingPage "727" @default.
• W2023181635 abstract "First-degree relatives of Type 1 (insulin-dependent) diabetic patients are at increased risk for developing clinical diabetes. The presence of islet cell or insulin autoantibodies further identifies relatives at greater risk, but not all immunologic-marker-positive relatives progress to disease. Beta-cell dysfunction, however, seems to be more prevalent than clinical Type 1 diabetes, since stable subclinical pancreatic Beta-cell dysfunction may occur. Antibodies against a Mr 64,000 (64K) islet Beta-cell protein, identified as glutamic acid decarboxylase, have been reported both at and several years prior to the clinical onset of Type 1 diabetes. We measured 64K antibodies in first-degree relatives with varying degrees of Beta-cell dysfunction and risk for subsequent Type 1 diabetes to determine whether 64K antibodies improve the predictive power of islet cell antibodies and/or insulin autoantibodies. In the Seattle Family Study first-degree relatives of Type 1 diabetic patients are followed prospectively using detailed Beta-cell function tests, insulin sensitivity, quantitative evaluation of islet cell antibodies and fluid phase assay insulin autoantibodies. 64K antibodies were measured using dog islets. Relatives were selected, based on Beta-cell function to represent individuals at high (n = 6) and low (n = 30) risk for subsequent Type 1 diabetes. The 30 low-risk individuals followed-up for 78 months, had stable Beta-cell function, and six (20%) were negative for all autoantibodies, ten (33%) were positive for insulin autoantibodies, 16 (53%) were islet cell antibody positive while six (20%) were positive for 64K antibodies.(ABSTRACT TRUNCATED AT 250 WORDS)" @default.
• W2023181635 created "2016-06-24" @default.
• W2023181635 creator A5005436471 @default.
• W2023181635 creator A5008841181 @default.
• W2023181635 creator A5023050264 @default.
• W2023181635 creator A5037171765 @default.
• W2023181635 creator A5046141743 @default.
• W2023181635 creator A5056814552 @default.
• W2023181635 creator A5090988731 @default.
• W2023181635 date "1991-10-01" @default.
• W2023181635 modified "2023-09-26" @default.
• W2023181635 title "Risk for developing Type 1 (insulin-dependent) diabetes mellitus and the presence of islet 64K antibodies" @default.
• W2023181635 cites W1192663989 @default.
• W2023181635 cites W188332221 @default.
• W2023181635 cites W1949772429 @default.
• W2023181635 cites W1966670737 @default.
• W2023181635 cites W1973972926 @default.
• W2023181635 cites W1977962868 @default.
• W2023181635 cites W1982628265 @default.
• W2023181635 cites W1990305944 @default.
• W2023181635 cites W1993325569 @default.
• W2023181635 cites W1994824720 @default.
• W2023181635 cites W1998808646 @default.
• W2023181635 cites W2001216921 @default.
• W2023181635 cites W2006439339 @default.
• W2023181635 cites W2011567860 @default.
• W2023181635 cites W2018289835 @default.
• W2023181635 cites W2019400285 @default.
• W2023181635 cites W2019605333 @default.
• W2023181635 cites W2019972832 @default.
• W2023181635 cites W2020125507 @default.
• W2023181635 cites W2024571096 @default.
• W2023181635 cites W2026889435 @default.
• W2023181635 cites W2035321298 @default.
• W2023181635 cites W2038816020 @default.
• W2023181635 cites W2039743782 @default.
• W2023181635 cites W2040437609 @default.
• W2023181635 cites W2047885243 @default.
• W2023181635 cites W2050044633 @default.
• W2023181635 cites W2052980275 @default.
• W2023181635 cites W2069846186 @default.
• W2023181635 cites W2070972996 @default.
• W2023181635 cites W2072652145 @default.
• W2023181635 cites W2077924494 @default.
• W2023181635 cites W2078165851 @default.
• W2023181635 cites W2088364920 @default.
• W2023181635 cites W2092251693 @default.
• W2023181635 cites W2095783416 @default.
• W2023181635 cites W2100837269 @default.
• W2023181635 cites W2108841007 @default.
• W2023181635 cites W2115804269 @default.
• W2023181635 cites W2122194908 @default.
• W2023181635 cites W2125624587 @default.
• W2023181635 cites W2127740228 @default.
• W2023181635 cites W2130171861 @default.
• W2023181635 cites W2133131602 @default.
• W2023181635 cites W2140655516 @default.
• W2023181635 cites W2142796657 @default.
• W2023181635 cites W2316713837 @default.
• W2023181635 cites W2334639754 @default.
• W2023181635 cites W2425263207 @default.
• W2023181635 cites W348880069 @default.
• W2023181635 cites W4232525488 @default.
• W2023181635 cites W4253414258 @default.
• W2023181635 cites W4290430973 @default.
• W2023181635 cites W4300788853 @default.
• W2023181635 doi "https://doi.org/10.1007/bf00401518" @default.
• W2023181635 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/1959705" @default.
• W2023181635 hasPublicationYear "1991" @default.
• W2023181635 type Work @default.
• W2023181635 sameAs 2023181635 @default.
• W2023181635 citedByCount "48" @default.
• W2023181635 countsByYear W20231816352013 @default.
• W2023181635 countsByYear W20231816352014 @default.
• W2023181635 countsByYear W20231816352019 @default.
• W2023181635 crossrefType "journal-article" @default.
• W2023181635 hasAuthorship W2023181635A5005436471 @default.
• W2023181635 hasAuthorship W2023181635A5008841181 @default.
• W2023181635 hasAuthorship W2023181635A5023050264 @default.
• W2023181635 hasAuthorship W2023181635A5037171765 @default.
• W2023181635 hasAuthorship W2023181635A5046141743 @default.
• W2023181635 hasAuthorship W2023181635A5056814552 @default.
• W2023181635 hasAuthorship W2023181635A5090988731 @default.
• W2023181635 hasBestOaLocation W20231816351 @default.
• W2023181635 hasConcept C113280763 @default.
• W2023181635 hasConcept C126322002 @default.
• W2023181635 hasConcept C134018914 @default.
• W2023181635 hasConcept C159654299 @default.
• W2023181635 hasConcept C163764329 @default.
• W2023181635 hasConcept C165220095 @default.
• W2023181635 hasConcept C203014093 @default.
• W2023181635 hasConcept C2776828364 @default.
• W2023181635 hasConcept C2777180221 @default.
• W2023181635 hasConcept C2779306644 @default.
• W2023181635 hasConcept C2779862289 @default.
• W2023181635 hasConcept C2781179581 @default.
• W2023181635 hasConcept C2781232474 @default.
• W2023181635 hasConcept C555293320 @default.

• next