FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2023181815> ?p ?o ?g. }

• W2023181815 endingPage "474" @default.
• W2023181815 startingPage "467" @default.
• W2023181815 abstract "Abstract The effect of terpinen-4-ol was studied on rabbit duodenum in-vitro. Terpinen-4-ol induced relaxation of the basal tonus (IC50 170.2 (95% confidence interval, 175–204) μm) with a maximal relaxant response of 180.4 ± 3.9% (n = 6) of the contraction induced by 60 mm [K+]. The maximal relaxation induced in control conditions was not affected (P&gt;0.05) by pretreatment of the tissues with phentolamine (50 μm) or propranolol (10 μm), Ng nitro-l-arginine methyl ester (L-NAME; 1 mm), 1H-(1,2,4)-oxadiazolo[4,3-a]quinoxalin-1-one (ODQ; 100 μm), hexamethonium (1 mm), tetrodotoxin (1 μm), the mixture charybdotoxin-apamin (1 μm), glibenclamide (10 μm), 4-aminopyridine (10 μm) or tetraethylammonium (100 μm). In addition, terpinen-4-ol completely relaxed tissues precontracted with 60 mm [K+] solutions (IC50 325.9 (245.1–433.1) μm) and also blocked (IC50 154.7 (117.7–191.7) μm) the phasic component of this contraction. At a concentration of 195 and 650 μm it reduced by 41.3 ± 3.4% and 75.4 ± 3.1%, respectively the maximal contractile response to Ca2+ in depolarized duodenum. Terpinen-4-ol completely blocked the component of carbachol-induced contraction, which was resistent to nifedipine (100 μm) pretreatment or to a Ca2+-free solution. These data show that terpinen-4-ol relaxes intestinal smooth muscle and suggest that this effect is myogenic in nature and depends on calcium antagonism." @default.
• W2023181815 created "2016-06-24" @default.
• W2023181815 creator A5010251561 @default.
• W2023181815 creator A5019601039 @default.
• W2023181815 creator A5037201000 @default.
• W2023181815 creator A5037736362 @default.
• W2023181815 creator A5057220590 @default.
• W2023181815 creator A5071243209 @default.
• W2023181815 date "2005-04-01" @default.
• W2023181815 modified "2023-09-27" @default.
• W2023181815 title "Terpinen-4-ol: mechanisms of relaxation on rabbit duodenum" @default.
• W2023181815 cites W1844605916 @default.
• W2023181815 cites W1963841855 @default.
• W2023181815 cites W1967307504 @default.
• W2023181815 cites W1968138649 @default.
• W2023181815 cites W1980166477 @default.
• W2023181815 cites W1985940938 @default.
• W2023181815 cites W1991504761 @default.
• W2023181815 cites W1998573264 @default.
• W2023181815 cites W1999528551 @default.
• W2023181815 cites W2005263270 @default.
• W2023181815 cites W2009075953 @default.
• W2023181815 cites W2009265410 @default.
• W2023181815 cites W2021844778 @default.
• W2023181815 cites W2024356344 @default.
• W2023181815 cites W2042973128 @default.
• W2023181815 cites W2050043844 @default.
• W2023181815 cites W2075597904 @default.
• W2023181815 cites W2084021290 @default.
• W2023181815 cites W2093448792 @default.
• W2023181815 cites W2099848441 @default.
• W2023181815 cites W2101074661 @default.
• W2023181815 cites W2106956351 @default.
• W2023181815 cites W2114703479 @default.
• W2023181815 cites W2140051040 @default.
• W2023181815 cites W2149329819 @default.
• W2023181815 cites W2153111437 @default.
• W2023181815 cites W2170631493 @default.
• W2023181815 cites W2281938476 @default.
• W2023181815 cites W2324912146 @default.
• W2023181815 cites W4361979926 @default.
• W2023181815 doi "https://doi.org/10.1211/0022357055696" @default.
• W2023181815 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15831207" @default.
• W2023181815 hasPublicationYear "2005" @default.
• W2023181815 type Work @default.
• W2023181815 sameAs 2023181815 @default.
• W2023181815 citedByCount "13" @default.
• W2023181815 countsByYear W20231818152013 @default.
• W2023181815 countsByYear W20231818152014 @default.
• W2023181815 countsByYear W20231818152015 @default.
• W2023181815 countsByYear W20231818152017 @default.
• W2023181815 countsByYear W20231818152018 @default.
• W2023181815 countsByYear W20231818152019 @default.
• W2023181815 countsByYear W20231818152020 @default.
• W2023181815 countsByYear W20231818152021 @default.
• W2023181815 countsByYear W20231818152022 @default.
• W2023181815 crossrefType "journal-article" @default.
• W2023181815 hasAuthorship W2023181815A5010251561 @default.
• W2023181815 hasAuthorship W2023181815A5019601039 @default.
• W2023181815 hasAuthorship W2023181815A5037201000 @default.
• W2023181815 hasAuthorship W2023181815A5037736362 @default.
• W2023181815 hasAuthorship W2023181815A5057220590 @default.
• W2023181815 hasAuthorship W2023181815A5071243209 @default.
• W2023181815 hasBestOaLocation W20231818151 @default.
• W2023181815 hasConcept C126322002 @default.
• W2023181815 hasConcept C134018914 @default.
• W2023181815 hasConcept C163415756 @default.
• W2023181815 hasConcept C170493617 @default.
• W2023181815 hasConcept C178790620 @default.
• W2023181815 hasConcept C185592680 @default.
• W2023181815 hasConcept C2775893369 @default.
• W2023181815 hasConcept C2776050358 @default.
• W2023181815 hasConcept C2776741303 @default.
• W2023181815 hasConcept C2776809568 @default.
• W2023181815 hasConcept C2776919887 @default.
• W2023181815 hasConcept C2778151854 @default.
• W2023181815 hasConcept C2778988552 @default.
• W2023181815 hasConcept C2779066535 @default.
• W2023181815 hasConcept C2779768347 @default.
• W2023181815 hasConcept C2780253649 @default.
• W2023181815 hasConcept C2780419564 @default.
• W2023181815 hasConcept C2781295685 @default.
• W2023181815 hasConcept C517785266 @default.
• W2023181815 hasConcept C519063684 @default.
• W2023181815 hasConcept C55493867 @default.
• W2023181815 hasConcept C555293320 @default.
• W2023181815 hasConcept C71924100 @default.
• W2023181815 hasConcept C86803240 @default.
• W2023181815 hasConceptScore W2023181815C126322002 @default.
• W2023181815 hasConceptScore W2023181815C134018914 @default.
• W2023181815 hasConceptScore W2023181815C163415756 @default.
• W2023181815 hasConceptScore W2023181815C170493617 @default.
• W2023181815 hasConceptScore W2023181815C178790620 @default.
• W2023181815 hasConceptScore W2023181815C185592680 @default.
• W2023181815 hasConceptScore W2023181815C2775893369 @default.
• W2023181815 hasConceptScore W2023181815C2776050358 @default.
• W2023181815 hasConceptScore W2023181815C2776741303 @default.
• W2023181815 hasConceptScore W2023181815C2776809568 @default.

• next