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• W2023184347 abstract "Many bacterial pathogens rely on a conserved membrane histidine sensor kinase, QseC, to respond to host adrenergic signaling molecules and bacterial signals in order to promote the expression of virulence factors. Using a high-throughput screen, we identified a small molecule, LED209, that inhibits the binding of signals to QseC, preventing its autophosphorylation and consequently inhibiting QseC-mediated activation of virulence gene expression. LED209 is not toxic and does not inhibit pathogen growth; however, this compound markedly inhibits the virulence of several pathogens in vitro and in vivo in animals. Inhibition of signaling offers a strategy for the development of broad-spectrum antimicrobial drugs." @default.
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• W2023184347 date "2008-08-22" @default.
• W2023184347 modified "2023-10-17" @default.
• W2023184347 title "Targeting QseC Signaling and Virulence for Antibiotic Development" @default.
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• W2023184347 doi "https://doi.org/10.1126/science.1160354" @default.
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