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• W2023184567 abstract "The release of [3H]neurotransmitters was used as a functional assay to assess the actions of selected neurotoxins on the synaptosomal membranes prepared from the invertebrate nervous systems of squid and house fly. A reproducible release of [3]neurotransmitter was evoked by pulsed-depolarization in the presence of elevated K+ or of veratridine. Pretreatment with deltamethrin resulted in a substantial enhancement of [3H]neuro-transmitter release during pulsed-depolarization. This enhanced neurotransmitter release was greatly reduced or absent when synaptosomes of knockdown-resistant house flies were examined. No enhanced neurotransmitter release due to deltamethrin pretreatment was apparent from any synaptosomal preparation under non-depolarizing conditions. Under similar conditions, collaborative experiments demonstrated that deltamethrin causes a significant change in protein phosphorylation activities which follow depolarization. The most significant change caused by deltamethrin was the prolonged elevation of the level of phosphorylation on a number of key synaptic proteins beyond the normal time of their recovery to the dephosphorylated state. The most notable protein reacting to deltamethrin in this manner was calcium-cadlmodulin-dependent protein kinase." @default.
• W2023184567 created "2016-06-24" @default.
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• W2023184567 date "1991-01-01" @default.
• W2023184567 modified "2023-09-25" @default.
• W2023184567 title "Enhancement of neurotransmitter release from invertebrate synaptosomes by pyrethroids during pulsed-depolarization: A functional assay for effects on repolarization" @default.
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• W2023184567 doi "https://doi.org/10.1002/ps.2780310109" @default.
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