Matches in SemOpenAlex for { <https://semopenalex.org/work/W2023184744> ?p ?o ?g. }
- W2023184744 endingPage "S96" @default.
- W2023184744 startingPage "S87" @default.
- W2023184744 abstract "Whether autoimmunity results primarily from a defect of the immune system, target organ dysfunction, or both remains an open issue in most human autoimmune diseases. The highly multigenic background on which diabetes develops in the NOD mouse and in the human suggests that numerous gene variants associate in contributing to activation of autoimmunity to β-cells. Both immune genes and islet-related genes are involved. The presence of β-cells is required for initiation of diabetes autoimmunity to proceed. Available experiments in the NOD mouse and epidemiological evidence in the human point to proinsulin as a key autoantigen in diabetes. The functional importance of insulin, the high number of autoantigens characterized at different stages of diabetes, and their clustering within β-cell subparticles point to the islet as a starting point in the initiation phase of the disease. Genes that direct the autoimmune reaction toward the β-cell target, autoantigens that are recognized by autoreactive B- and T-cells along the autoimmune process, the importance of β-cells in the activation of autoreactive lymphocytes, and the expression level of key β-cell molecules along diabetes development are successively considered in this review." @default.
- W2023184744 created "2016-06-24" @default.
- W2023184744 creator A5015422590 @default.
- W2023184744 creator A5026786945 @default.
- W2023184744 creator A5039277778 @default.
- W2023184744 creator A5075295048 @default.
- W2023184744 creator A5090091432 @default.
- W2023184744 date "2005-12-01" @default.
- W2023184744 modified "2023-09-27" @default.
- W2023184744 title "Role of β-Cells in Type 1 Diabetes Pathogenesis" @default.
- W2023184744 cites W1488223402 @default.
- W2023184744 cites W1532682782 @default.
- W2023184744 cites W1608281712 @default.
- W2023184744 cites W1808727710 @default.
- W2023184744 cites W1912307887 @default.
- W2023184744 cites W1967479541 @default.
- W2023184744 cites W1974729050 @default.
- W2023184744 cites W1976020265 @default.
- W2023184744 cites W1992197229 @default.
- W2023184744 cites W1997827211 @default.
- W2023184744 cites W2006673918 @default.
- W2023184744 cites W2015941944 @default.
- W2023184744 cites W2016410422 @default.
- W2023184744 cites W2016976370 @default.
- W2023184744 cites W2020206943 @default.
- W2023184744 cites W2026152930 @default.
- W2023184744 cites W2026468137 @default.
- W2023184744 cites W2031426031 @default.
- W2023184744 cites W2034306860 @default.
- W2023184744 cites W2038909539 @default.
- W2023184744 cites W2041711928 @default.
- W2023184744 cites W2044971047 @default.
- W2023184744 cites W2046749316 @default.
- W2023184744 cites W2049710430 @default.
- W2023184744 cites W2051487641 @default.
- W2023184744 cites W2051490806 @default.
- W2023184744 cites W2051754218 @default.
- W2023184744 cites W2060440448 @default.
- W2023184744 cites W2065233610 @default.
- W2023184744 cites W2067651108 @default.
- W2023184744 cites W2074891952 @default.
- W2023184744 cites W2079448776 @default.
- W2023184744 cites W2079788829 @default.
- W2023184744 cites W2087184465 @default.
- W2023184744 cites W2087303623 @default.
- W2023184744 cites W2091933744 @default.
- W2023184744 cites W2093902228 @default.
- W2023184744 cites W2094108596 @default.
- W2023184744 cites W2096094429 @default.
- W2023184744 cites W2097101529 @default.
- W2023184744 cites W2107144645 @default.
- W2023184744 cites W2110178731 @default.
- W2023184744 cites W2113799022 @default.
- W2023184744 cites W2120329743 @default.
- W2023184744 cites W2121441836 @default.
- W2023184744 cites W2121789150 @default.
- W2023184744 cites W2126636162 @default.
- W2023184744 cites W2127788605 @default.
- W2023184744 cites W2132160710 @default.
- W2023184744 cites W2134516820 @default.
- W2023184744 cites W2138705990 @default.
- W2023184744 cites W2141405570 @default.
- W2023184744 cites W2142232563 @default.
- W2023184744 cites W2143433115 @default.
- W2023184744 cites W2145348622 @default.
- W2023184744 cites W2145720279 @default.
- W2023184744 cites W2146776232 @default.
- W2023184744 cites W2148422620 @default.
- W2023184744 cites W2153929491 @default.
- W2023184744 cites W2155178236 @default.
- W2023184744 cites W2163767652 @default.
- W2023184744 cites W2166725781 @default.
- W2023184744 doi "https://doi.org/10.2337/diabetes.54.suppl_2.s87" @default.
- W2023184744 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16306346" @default.
- W2023184744 hasPublicationYear "2005" @default.
- W2023184744 type Work @default.
- W2023184744 sameAs 2023184744 @default.
- W2023184744 citedByCount "49" @default.
- W2023184744 countsByYear W20231847442012 @default.
- W2023184744 countsByYear W20231847442013 @default.
- W2023184744 countsByYear W20231847442014 @default.
- W2023184744 countsByYear W20231847442015 @default.
- W2023184744 countsByYear W20231847442017 @default.
- W2023184744 countsByYear W20231847442018 @default.
- W2023184744 countsByYear W20231847442019 @default.
- W2023184744 countsByYear W20231847442021 @default.
- W2023184744 countsByYear W20231847442022 @default.
- W2023184744 crossrefType "journal-article" @default.
- W2023184744 hasAuthorship W2023184744A5015422590 @default.
- W2023184744 hasAuthorship W2023184744A5026786945 @default.
- W2023184744 hasAuthorship W2023184744A5039277778 @default.
- W2023184744 hasAuthorship W2023184744A5075295048 @default.
- W2023184744 hasAuthorship W2023184744A5090091432 @default.
- W2023184744 hasBestOaLocation W20231847441 @default.
- W2023184744 hasConcept C134018914 @default.
- W2023184744 hasConcept C159654299 @default.
- W2023184744 hasConcept C203014093 @default.
- W2023184744 hasConcept C2778013207 @default.