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- W2023185717 abstract "Rationale During the past decade, the therapeutic approach to patients affected by metastatic colorectal carcinoma has dramatically changed after the introduction of new active drugs into clinical practice. Irinotecan Irinotecan has shown response in 5-fluorouracil (5FU)–pretreated patients and similar activity was observed with leucovorin (LV)-modulated 5-FU in first-line treatment. 1 Two large trials have randomly assessed the addition of irinotecan to 5-FU/LV regimens in patients with metastatic cancer. 2,3 In the US trial, irinotecan 125 mg/m 2 given intravenously (I.V.) was added to LV 20 mg/m 2 I.V. bolus and 5-FU 500 mg/m 2 I.V. bolus weekly for 4 consecutive weeks followed by 2 weeks of rest. In comparison with the reference regimen, response rate was significantly greater (39% vs. 21%), and time to progression (7.0 months vs. 4.3 months) and overall survival were significantly longer (14.8 months vs. 12.6 months). 2 In the European trial, patients received irinotecan 80 mg/m 2 immediately preceded by an LV-modulated 5-FU I.V. infusion of 2300 mg/m 2 for 24 hours weekly, irinotecan 180 mg/m 2 immediately preceded by an LV-modulated 5-FU infusion of 400 mg/m 2 bolus plus 600 mg/m 2 for 22 hours twice" @default.
- W2023185717 created "2016-06-24" @default.
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- W2023185717 date "2003-11-01" @default.
- W2023185717 modified "2023-09-26" @default.
- W2023185717 title "Randomized Trial Comparing the Addition of Oxaliplatin or Irinotecan to High-Dose Leucovorin and 5-Fluorouracil Intravenous Bolus Every Two Weeks in Metastatic Colorectal Carcinoma: Southern Italy Cooperative Oncology Group 0103" @default.
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- W2023185717 doi "https://doi.org/10.3816/ccc.2003.n.025" @default.
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