Matches in SemOpenAlex for { <https://semopenalex.org/work/W2023185750> ?p ?o ?g. }
- W2023185750 endingPage "5189" @default.
- W2023185750 startingPage "5181" @default.
- W2023185750 abstract "Abstract The BRCA1 tumor suppressor contributes to the repair of DNA double-strand breaks (DSB) through homologous recombination, but the mechanism is unknown. The rapid accumulation of BRCA1 into nuclear foci in response to induction of DNA breaks suggests that BRCA1 may function in an early step in the repair pathway. We examined the role of BRCA1 in one such early step, the resection of DSBs to generate ssDNA. The appearance of ssDNA in response to ionizing radiation is similar to that of BRCA1 foci formation, suggesting that the two processes are related. Furthermore, BRCA1 colocalizes to ssDNA sites induced by ionizing radiation. Overexpression of BRCA1 causes an increase in cells exhibiting ssDNA induced by ionizing radiation. Mutant BRCA1 that lacks the COOH-terminal BRCT domain also promotes ssDNA but fails to form nuclear foci. Knockdown of BRCA1 expression reduces ssDNA and Rad51 foci formation in response to ionizing radiation. These results indicate that BRCA1 promotes induction of ssDNA in response to ionizing radiation and accumulates at sites of ssDNA. (Cancer Res 2006; 66(10): 5181-9)" @default.
- W2023185750 created "2016-06-24" @default.
- W2023185750 creator A5066107604 @default.
- W2023185750 creator A5068155775 @default.
- W2023185750 creator A5090055542 @default.
- W2023185750 date "2006-05-15" @default.
- W2023185750 modified "2023-10-01" @default.
- W2023185750 title "BRCA1 Promotes Induction of ssDNA by Ionizing Radiation" @default.
- W2023185750 cites W1968469516 @default.
- W2023185750 cites W1969150779 @default.
- W2023185750 cites W1971152401 @default.
- W2023185750 cites W1972710550 @default.
- W2023185750 cites W1976960697 @default.
- W2023185750 cites W1977035912 @default.
- W2023185750 cites W1978183360 @default.
- W2023185750 cites W1986627314 @default.
- W2023185750 cites W1986730363 @default.
- W2023185750 cites W1994300590 @default.
- W2023185750 cites W2000595178 @default.
- W2023185750 cites W2007214871 @default.
- W2023185750 cites W2010369105 @default.
- W2023185750 cites W2016760769 @default.
- W2023185750 cites W2019405732 @default.
- W2023185750 cites W2024131694 @default.
- W2023185750 cites W2034317592 @default.
- W2023185750 cites W2038260399 @default.
- W2023185750 cites W2039435798 @default.
- W2023185750 cites W2053003311 @default.
- W2023185750 cites W2057949133 @default.
- W2023185750 cites W2059365987 @default.
- W2023185750 cites W2061672761 @default.
- W2023185750 cites W2068638854 @default.
- W2023185750 cites W2072981858 @default.
- W2023185750 cites W2076172602 @default.
- W2023185750 cites W2084491471 @default.
- W2023185750 cites W2088179903 @default.
- W2023185750 cites W2105395542 @default.
- W2023185750 cites W2109465247 @default.
- W2023185750 cites W2109528117 @default.
- W2023185750 cites W2110948748 @default.
- W2023185750 cites W2115626825 @default.
- W2023185750 cites W2119999819 @default.
- W2023185750 cites W2130622650 @default.
- W2023185750 cites W2136849872 @default.
- W2023185750 cites W2139533668 @default.
- W2023185750 cites W2164890615 @default.
- W2023185750 cites W2168225429 @default.
- W2023185750 cites W4206591058 @default.
- W2023185750 doi "https://doi.org/10.1158/0008-5472.can-05-3209" @default.
- W2023185750 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16707442" @default.
- W2023185750 hasPublicationYear "2006" @default.
- W2023185750 type Work @default.
- W2023185750 sameAs 2023185750 @default.
- W2023185750 citedByCount "91" @default.
- W2023185750 countsByYear W20231857502012 @default.
- W2023185750 countsByYear W20231857502013 @default.
- W2023185750 countsByYear W20231857502014 @default.
- W2023185750 countsByYear W20231857502015 @default.
- W2023185750 countsByYear W20231857502016 @default.
- W2023185750 countsByYear W20231857502017 @default.
- W2023185750 countsByYear W20231857502018 @default.
- W2023185750 countsByYear W20231857502019 @default.
- W2023185750 countsByYear W20231857502020 @default.
- W2023185750 countsByYear W20231857502021 @default.
- W2023185750 countsByYear W20231857502022 @default.
- W2023185750 countsByYear W20231857502023 @default.
- W2023185750 crossrefType "journal-article" @default.
- W2023185750 hasAuthorship W2023185750A5066107604 @default.
- W2023185750 hasAuthorship W2023185750A5068155775 @default.
- W2023185750 hasAuthorship W2023185750A5090055542 @default.
- W2023185750 hasBestOaLocation W20231857501 @default.
- W2023185750 hasConcept C102744134 @default.
- W2023185750 hasConcept C104317684 @default.
- W2023185750 hasConcept C111337013 @default.
- W2023185750 hasConcept C121332964 @default.
- W2023185750 hasConcept C134935766 @default.
- W2023185750 hasConcept C143065580 @default.
- W2023185750 hasConcept C143425029 @default.
- W2023185750 hasConcept C153911025 @default.
- W2023185750 hasConcept C173396325 @default.
- W2023185750 hasConcept C179185449 @default.
- W2023185750 hasConcept C18231593 @default.
- W2023185750 hasConcept C185544564 @default.
- W2023185750 hasConcept C185592680 @default.
- W2023185750 hasConcept C2779012473 @default.
- W2023185750 hasConcept C502942594 @default.
- W2023185750 hasConcept C54355233 @default.
- W2023185750 hasConcept C552990157 @default.
- W2023185750 hasConcept C86803240 @default.
- W2023185750 hasConcept C95444343 @default.
- W2023185750 hasConceptScore W2023185750C102744134 @default.
- W2023185750 hasConceptScore W2023185750C104317684 @default.
- W2023185750 hasConceptScore W2023185750C111337013 @default.
- W2023185750 hasConceptScore W2023185750C121332964 @default.
- W2023185750 hasConceptScore W2023185750C134935766 @default.
- W2023185750 hasConceptScore W2023185750C143065580 @default.
- W2023185750 hasConceptScore W2023185750C143425029 @default.
- W2023185750 hasConceptScore W2023185750C153911025 @default.