Matches in SemOpenAlex for { <https://semopenalex.org/work/W2023187813> ?p ?o ?g. }
- W2023187813 endingPage "274" @default.
- W2023187813 startingPage "257" @default.
- W2023187813 abstract "Injection into the nucleus basalis of the rat of preaggregated Abeta(1-42) produced a congophylic deposit and microglial and astrocyte activation and infiltration and caused a strong inflammatory reaction characterized by IL-1beta production, increased inducible cyclooxygenase (COX-2), and inducible nitric oxide synthase (iNOS) expression. Many phospho-p38MAPK-positive cells were observed around the deposit at 7 days after Abeta injection. Phospho-p38MAPK colocalized with activated microglial cells, but not astrocytes. The inflammatory reaction was accompanied by cholinergic hypofunction. We investigated the protective effect of the selective COX-2 inhibitor rofecoxib in attenuating the inflammatory response and neurodegeneration evoked by Abeta(1-42). Rofecoxib (3 mg/kg/day, 7 days) reduced microglia and astrocyte activation, iNOS induction, and p38MAPK activation to control levels. Cholinergic hypofunction was also significantly attenuated by treatment with rofecoxib. We show here for the first time in vivo the pivotal role played by the p38MAPK microglial signal transduction pathway in the inflammatory response to the Abeta(1-42) deposit." @default.
- W2023187813 created "2016-06-24" @default.
- W2023187813 creator A5010729201 @default.
- W2023187813 creator A5018445969 @default.
- W2023187813 creator A5019565420 @default.
- W2023187813 creator A5019578514 @default.
- W2023187813 creator A5053047266 @default.
- W2023187813 creator A5061850102 @default.
- W2023187813 creator A5067663192 @default.
- W2023187813 creator A5090014681 @default.
- W2023187813 date "2002-11-01" @default.
- W2023187813 modified "2023-10-01" @default.
- W2023187813 title "β-Amyloid-Induced Inflammation and Cholinergic Hypofunction in the Rat Brain in Vivo: Involvement of the p38MAPK Pathway" @default.
- W2023187813 cites W1572715302 @default.
- W2023187813 cites W1582674379 @default.
- W2023187813 cites W1591177630 @default.
- W2023187813 cites W1729010372 @default.
- W2023187813 cites W1848864628 @default.
- W2023187813 cites W1915946375 @default.
- W2023187813 cites W1966103571 @default.
- W2023187813 cites W1973678070 @default.
- W2023187813 cites W1974198922 @default.
- W2023187813 cites W1975506293 @default.
- W2023187813 cites W1976690335 @default.
- W2023187813 cites W1980940682 @default.
- W2023187813 cites W1982064952 @default.
- W2023187813 cites W1989691222 @default.
- W2023187813 cites W1991219972 @default.
- W2023187813 cites W1994047676 @default.
- W2023187813 cites W1994067502 @default.
- W2023187813 cites W2000663601 @default.
- W2023187813 cites W2001162433 @default.
- W2023187813 cites W2001751920 @default.
- W2023187813 cites W2007986629 @default.
- W2023187813 cites W2013052548 @default.
- W2023187813 cites W2013149569 @default.
- W2023187813 cites W2015163544 @default.
- W2023187813 cites W2019087169 @default.
- W2023187813 cites W2023207885 @default.
- W2023187813 cites W2030164772 @default.
- W2023187813 cites W2032731042 @default.
- W2023187813 cites W2036374416 @default.
- W2023187813 cites W2036542628 @default.
- W2023187813 cites W2039453997 @default.
- W2023187813 cites W2041078076 @default.
- W2023187813 cites W2042928324 @default.
- W2023187813 cites W2045560271 @default.
- W2023187813 cites W2050489727 @default.
- W2023187813 cites W2053642376 @default.
- W2023187813 cites W2057176833 @default.
- W2023187813 cites W2057622701 @default.
- W2023187813 cites W2064243975 @default.
- W2023187813 cites W2067350065 @default.
- W2023187813 cites W2068225545 @default.
- W2023187813 cites W2082431283 @default.
- W2023187813 cites W2082452384 @default.
- W2023187813 cites W2084043574 @default.
- W2023187813 cites W2085807260 @default.
- W2023187813 cites W2091448266 @default.
- W2023187813 cites W2098153006 @default.
- W2023187813 cites W2098719212 @default.
- W2023187813 cites W2104163119 @default.
- W2023187813 cites W2108237688 @default.
- W2023187813 cites W2113690827 @default.
- W2023187813 cites W2116784956 @default.
- W2023187813 cites W2117169037 @default.
- W2023187813 cites W2129377911 @default.
- W2023187813 cites W2134873827 @default.
- W2023187813 cites W2136439668 @default.
- W2023187813 cites W2143944971 @default.
- W2023187813 cites W2146901670 @default.
- W2023187813 cites W2149954869 @default.
- W2023187813 cites W2150336097 @default.
- W2023187813 cites W2152891521 @default.
- W2023187813 cites W2158676848 @default.
- W2023187813 cites W2159027833 @default.
- W2023187813 cites W233841868 @default.
- W2023187813 cites W4297846234 @default.
- W2023187813 doi "https://doi.org/10.1006/nbdi.2002.0538" @default.
- W2023187813 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12505419" @default.
- W2023187813 hasPublicationYear "2002" @default.
- W2023187813 type Work @default.
- W2023187813 sameAs 2023187813 @default.
- W2023187813 citedByCount "200" @default.
- W2023187813 countsByYear W20231878132012 @default.
- W2023187813 countsByYear W20231878132013 @default.
- W2023187813 countsByYear W20231878132014 @default.
- W2023187813 countsByYear W20231878132015 @default.
- W2023187813 countsByYear W20231878132016 @default.
- W2023187813 countsByYear W20231878132017 @default.
- W2023187813 countsByYear W20231878132018 @default.
- W2023187813 countsByYear W20231878132019 @default.
- W2023187813 countsByYear W20231878132020 @default.
- W2023187813 countsByYear W20231878132021 @default.
- W2023187813 countsByYear W20231878132022 @default.
- W2023187813 countsByYear W20231878132023 @default.
- W2023187813 crossrefType "journal-article" @default.
- W2023187813 hasAuthorship W2023187813A5010729201 @default.