Matches in SemOpenAlex for { <https://semopenalex.org/work/W2023188672> ?p ?o ?g. }
- W2023188672 endingPage "716" @default.
- W2023188672 startingPage "708" @default.
- W2023188672 abstract "Research into the cellular processing and functional properties of the amyloid beta-protein precursor (beta PP) and its secreted derivatives is rapidly accelerating and drawing interest from many investigators outside the field of Alzheimer's disease pathobiology. Recent in vitro studies suggest multiple activities for the major secreted product, beta PPs, including protease inhibition, growth promotion, neuroprotection and stimulation of a signal transduction pathway. Surprisingly, the hydrophobic amyloid beta-protein fragment is also constitutively secreted. Its generation occurs in part during the endocytosis of cell-surface beta PP molecules. Processing of beta PP via amyloidogenic versus non-amyloidogenic pathways is under complex regulation by various first and second messengers. Analyses of beta PP missense mutations and of the effects of apolipoprotein E genotype lend new support to the hypothesis that accelerated amyloid beta protein deposition plays a pivotal role in the genesis of Alzheimer's disease." @default.
- W2023188672 created "2016-06-24" @default.
- W2023188672 creator A5087935119 @default.
- W2023188672 date "1994-10-01" @default.
- W2023188672 modified "2023-10-16" @default.
- W2023188672 title "Amyloid β-protein precursor: new clues to the genesis of Alzheimer's disease" @default.
- W2023188672 cites W1502820594 @default.
- W2023188672 cites W1504320357 @default.
- W2023188672 cites W1510308646 @default.
- W2023188672 cites W1539232350 @default.
- W2023188672 cites W1554535382 @default.
- W2023188672 cites W1598870275 @default.
- W2023188672 cites W1600007560 @default.
- W2023188672 cites W1736480315 @default.
- W2023188672 cites W1960543132 @default.
- W2023188672 cites W1964172387 @default.
- W2023188672 cites W1967237003 @default.
- W2023188672 cites W1969810313 @default.
- W2023188672 cites W1973238216 @default.
- W2023188672 cites W1979543098 @default.
- W2023188672 cites W1980906872 @default.
- W2023188672 cites W2004102314 @default.
- W2023188672 cites W2011424449 @default.
- W2023188672 cites W2020460543 @default.
- W2023188672 cites W2024696690 @default.
- W2023188672 cites W2030641075 @default.
- W2023188672 cites W2033356439 @default.
- W2023188672 cites W2033382511 @default.
- W2023188672 cites W2036362108 @default.
- W2023188672 cites W2041235538 @default.
- W2023188672 cites W2062199825 @default.
- W2023188672 cites W2071340676 @default.
- W2023188672 cites W2071953900 @default.
- W2023188672 cites W2073806885 @default.
- W2023188672 cites W2075453627 @default.
- W2023188672 cites W2086278983 @default.
- W2023188672 cites W2087982057 @default.
- W2023188672 cites W2090150925 @default.
- W2023188672 cites W2090271811 @default.
- W2023188672 cites W2090390963 @default.
- W2023188672 cites W2091924214 @default.
- W2023188672 cites W2127061690 @default.
- W2023188672 cites W2134385751 @default.
- W2023188672 cites W2139818289 @default.
- W2023188672 cites W2148999943 @default.
- W2023188672 cites W2152901985 @default.
- W2023188672 cites W2158748165 @default.
- W2023188672 cites W2159846320 @default.
- W2023188672 cites W2166681711 @default.
- W2023188672 cites W2464865057 @default.
- W2023188672 doi "https://doi.org/10.1016/0959-4388(94)90014-0" @default.
- W2023188672 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/7849528" @default.
- W2023188672 hasPublicationYear "1994" @default.
- W2023188672 type Work @default.
- W2023188672 sameAs 2023188672 @default.
- W2023188672 citedByCount "95" @default.
- W2023188672 countsByYear W20231886722012 @default.
- W2023188672 countsByYear W20231886722013 @default.
- W2023188672 countsByYear W20231886722014 @default.
- W2023188672 countsByYear W20231886722015 @default.
- W2023188672 countsByYear W20231886722016 @default.
- W2023188672 countsByYear W20231886722017 @default.
- W2023188672 countsByYear W20231886722018 @default.
- W2023188672 countsByYear W20231886722019 @default.
- W2023188672 countsByYear W20231886722021 @default.
- W2023188672 countsByYear W20231886722023 @default.
- W2023188672 crossrefType "journal-article" @default.
- W2023188672 hasAuthorship W2023188672A5087935119 @default.
- W2023188672 hasConcept C126322002 @default.
- W2023188672 hasConcept C1491633281 @default.
- W2023188672 hasConcept C169760540 @default.
- W2023188672 hasConcept C180081513 @default.
- W2023188672 hasConcept C185592680 @default.
- W2023188672 hasConcept C2776156579 @default.
- W2023188672 hasConcept C2777633098 @default.
- W2023188672 hasConcept C2779134260 @default.
- W2023188672 hasConcept C2779281246 @default.
- W2023188672 hasConcept C28005876 @default.
- W2023188672 hasConcept C31705614 @default.
- W2023188672 hasConcept C36103677 @default.
- W2023188672 hasConcept C502032728 @default.
- W2023188672 hasConcept C55493867 @default.
- W2023188672 hasConcept C57089818 @default.
- W2023188672 hasConcept C59822182 @default.
- W2023188672 hasConcept C62478195 @default.
- W2023188672 hasConcept C71924100 @default.
- W2023188672 hasConcept C86803240 @default.
- W2023188672 hasConcept C95444343 @default.
- W2023188672 hasConceptScore W2023188672C126322002 @default.
- W2023188672 hasConceptScore W2023188672C1491633281 @default.
- W2023188672 hasConceptScore W2023188672C169760540 @default.
- W2023188672 hasConceptScore W2023188672C180081513 @default.
- W2023188672 hasConceptScore W2023188672C185592680 @default.
- W2023188672 hasConceptScore W2023188672C2776156579 @default.
- W2023188672 hasConceptScore W2023188672C2777633098 @default.
- W2023188672 hasConceptScore W2023188672C2779134260 @default.
- W2023188672 hasConceptScore W2023188672C2779281246 @default.
- W2023188672 hasConceptScore W2023188672C28005876 @default.