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• W2023188723 abstract "CD4+/CD56+ hematodermic neoplasm (HN), formerly known as a blastic natural killer (NK) cell lymphoma, is a rare subtype of a cutaneous dendritic cell neoplasm notable for highly aggressive behavior. The characteristic features are: expression of the T‐helper/inducer cell marker CD4 and the NK‐cell marker CD56 in the absence of other T cell or NK‐cell specific markers. In particular, CD3 (surface or cytoplasmic) and CD2 are not expressed. Although T‐cell receptor (TCR) genes are generally reported to be in a germline configuration, we present an unusual variant of a CD4+/CD56+ HN with a clonal rearrangement of TCR genes. This feature of a CD4+/CD56+ HN has been only rarely reported. Recognition of the presence of clonal TCR gene rearrangements in a small subset of CD4+/CD56+ HN is important to avoid misdiagnosis of this entity as an unusual variant of a cutaneous T‐cell lymphoma." @default.
• W2023188723 created "2016-06-24" @default.
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• W2023188723 date "2008-05-06" @default.
• W2023188723 modified "2023-10-16" @default.
• W2023188723 title "CD4+/CD56+ hematodermic neoplasm: report of a rare variant with a T-cell receptor gene rearrangement" @default.
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• W2023188723 doi "https://doi.org/10.1111/j.1600-0560.2007.00845.x" @default.
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