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- W2023190977 abstract "Low-dose vaccination has been proposed as a cost-saving strategy to implement mass vaccination of neonates with hepatitis B (HB) vaccine, world-wide, particularly in developing countries. The effectiveness of low vaccine doses, however, needs to be evaluated and verified in newborns from different ethnic backgrounds. In this study, a recombinant HB vaccine (Heberbiovac) was administered in three different doses, including the standard 10 microg together with 5 and 2.5 microg to three groups of healthy Iranian neonates. Each group, consisting of 230-260 subjects, received triple doses of vaccine given i.m. at 0, 1.5 and 9 month intervals. Serum samples were collected 2-4 weeks after completion of vaccination, and anti-HBs antibody was quantitated by a sandwich ELISA. Seroprotection (anti-HBs>10 IU/L) was detected in 92, 97.4 and 96.1% of 2.5, 5 and 10 microg vaccine dose recipients, with geometric mean titer (GMT) of 4502, 5824 and 6104 IU/L, respectively. No significant differences were observed in seroprotection rate and GMT between the 10 and 5 microg dose recipients. Both parameters, however, were significantly lower in neonates vaccinated with a 2.5 microg vaccine dose (P<0.05 and P<0.001, respectively). These findings indicate induction of a strong protective immune response in healthy Iranian neonates by a low dose (5 microg) of the recombinant HB vaccine." @default.
- W2023190977 created "2016-06-24" @default.
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- W2023190977 date "2001-08-01" @default.
- W2023190977 modified "2023-09-23" @default.
- W2023190977 title "High seroprotection rate induced by low doses of a recombinant hepatitis B vaccine in healthy Iranian neonates" @default.
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- W2023190977 doi "https://doi.org/10.1016/s0264-410x(01)00183-9" @default.
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