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• W2023193193 abstract "The dopamine type-1 receptor has been implicated in major depressive disorder (MDD) by clinical and preclinical evidence from neuroimaging, post mortem, and behavioral studies. To date, however, selective in vivo assessment of D(1) receptors has been limited to the striatum in MDD samples manifesting anger attacks. We employed the PET radioligand, [(11)C]NNC-112, to selectively assess D(1) receptor binding in extrastriatal and striatal regions in a more generalized sample of MDD subjects. The [(11)C]NNC-112 nondisplaceable binding potential (BP(ND)) was assessed using PET in 18 unmedicated, currently depressed subjects with MDD and 19 healthy controls, and compared between groups using MRI-based region-of-interest analysis. The mean D(1) receptor BP(ND) was reduced (14%) in the left middle caudate of the MDD group relative to control group (p<0.05). Among the MDD subjects D(1) receptor BP(ND) in this region correlated negatively with illness duration (r=-0.53; p=0.02), and the left-to-right BP(ND) ratio correlated inversely with anhedonia ratings (r=-0.65, p=0.0040). The D(1) receptor BP(ND) was strongly lateralized in striatal regions (p<0.002 for main effects of hemisphere in accumbens area, putamen, and caudate). In post hoc analyses, a group-by-hemisphere-by-gender interaction was detected in the dorsal putamen, which was accounted for by a loss of the normal asymmetry in depressed women (F=7.33, p=0.01). These data extended a previous finding of decreased striatal D(1) receptor binding in an MDD sample manifesting anger attacks to a sample selected more generally according to MDD criteria. Our data also more specifically localized this abnormality in MDD to the left middle caudate, which is the target of afferent neural projections from the orbitofrontal and anterior cingulate cortices where neuropathological changes have been reported in MDD. Finally, D(1) receptor binding was asymmetrical across hemispheres in healthy humans, compatible with evidence that dopaminergic function in the striatum is lateralized during reward processing, voluntary movement, and self-stimulation behavior." @default.
• W2023193193 created "2016-06-24" @default.
• W2023193193 creator A5009265086 @default.
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• W2023193193 creator A5060908661 @default.
• W2023193193 creator A5071527129 @default.
• W2023193193 creator A5076640792 @default.
• W2023193193 date "2008-10-22" @default.
• W2023193193 modified "2023-10-01" @default.
• W2023193193 title "Dopamine Type-1 Receptor Binding in Major Depressive Disorder Assessed Using Positron Emission Tomography and [11C]NNC-112" @default.
• W2023193193 cites W124759840 @default.
• W2023193193 cites W1578186125 @default.
• W2023193193 cites W1936296662 @default.
• W2023193193 cites W1963781297 @default.
• W2023193193 cites W1964177118 @default.
• W2023193193 cites W1968287366 @default.
• W2023193193 cites W1969275478 @default.
• W2023193193 cites W1974453590 @default.
• W2023193193 cites W1976435745 @default.
• W2023193193 cites W1982627018 @default.
• W2023193193 cites W1985243541 @default.
• W2023193193 cites W1989203098 @default.
• W2023193193 cites W1989615119 @default.
• W2023193193 cites W1990005524 @default.
• W2023193193 cites W1993273089 @default.
• W2023193193 cites W1994364310 @default.
• W2023193193 cites W2000029267 @default.
• W2023193193 cites W2003194982 @default.
• W2023193193 cites W2011620025 @default.
• W2023193193 cites W2012723046 @default.
• W2023193193 cites W2013190001 @default.
• W2023193193 cites W2014119088 @default.
• W2023193193 cites W2014315897 @default.
• W2023193193 cites W2028980996 @default.
• W2023193193 cites W2029313053 @default.
• W2023193193 cites W2029809954 @default.
• W2023193193 cites W2030773481 @default.
• W2023193193 cites W2030871689 @default.
• W2023193193 cites W2033524647 @default.
• W2023193193 cites W2033770424 @default.
• W2023193193 cites W2038106385 @default.
• W2023193193 cites W2038449957 @default.
• W2023193193 cites W2038938389 @default.
• W2023193193 cites W2042938639 @default.
• W2023193193 cites W2044102937 @default.
• W2023193193 cites W2045038404 @default.
• W2023193193 cites W2045387058 @default.
• W2023193193 cites W2050827499 @default.
• W2023193193 cites W2053476648 @default.
• W2023193193 cites W2054843129 @default.
• W2023193193 cites W2059205836 @default.
• W2023193193 cites W2061833498 @default.
• W2023193193 cites W2062446797 @default.
• W2023193193 cites W2064559319 @default.
• W2023193193 cites W2065693683 @default.
• W2023193193 cites W2068622285 @default.
• W2023193193 cites W2076220976 @default.
• W2023193193 cites W2077319168 @default.
• W2023193193 cites W2078617761 @default.
• W2023193193 cites W2078815837 @default.
• W2023193193 cites W2080548270 @default.
• W2023193193 cites W2081505479 @default.
• W2023193193 cites W2084007108 @default.
• W2023193193 cites W2085538049 @default.
• W2023193193 cites W2086828943 @default.
• W2023193193 cites W2087205180 @default.
• W2023193193 cites W2088495467 @default.
• W2023193193 cites W2089546113 @default.
• W2023193193 cites W2090119590 @default.
• W2023193193 cites W2091864444 @default.
• W2023193193 cites W2091890724 @default.
• W2023193193 cites W2092507882 @default.
• W2023193193 cites W2094182702 @default.
• W2023193193 cites W2094713065 @default.
• W2023193193 cites W2095697295 @default.
• W2023193193 cites W2099987852 @default.
• W2023193193 cites W2101562854 @default.
• W2023193193 cites W2103299168 @default.
• W2023193193 cites W2104260598 @default.
• W2023193193 cites W2117518771 @default.
• W2023193193 cites W2121178670 @default.
• W2023193193 cites W2122188931 @default.
• W2023193193 cites W2130138967 @default.
• W2023193193 cites W2131823335 @default.
• W2023193193 cites W2132504226 @default.
• W2023193193 cites W2133371501 @default.
• W2023193193 cites W2138718114 @default.
• W2023193193 cites W2142544704 @default.
• W2023193193 cites W2146519542 @default.
• W2023193193 cites W2148726987 @default.
• W2023193193 cites W2149425620 @default.
• W2023193193 cites W2153693979 @default.
• W2023193193 cites W2160070901 @default.
• W2023193193 cites W2165545769 @default.
• W2023193193 cites W2169045155 @default.
• W2023193193 cites W2171521575 @default.
• W2023193193 cites W2174764226 @default.

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