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- W2023193778 abstract "Reported associations between air pollution and pulmonary and cardiovascular diseases prompted studies on the effects of gold nanoparticles (Au NP) on pulmonary surfactant function. Low levels (3.7 mol % Au/lipid, 0.98% wt/wt) markedly inhibited adsorption of a semisynthetic pulmonary surfactant (dipalmitoyl-phosphatidylcholine (DPPC)/palmitoyl-oleoyl-phosphatidylglycerol/surfactant protein B (SP-B); 70:30:1 wt %). Au NP also impeded the surfactant's ability to reduce surface tension (γ) to low levels during film compression and to respread during film expansion. Transmission electron microscopy showed that Au NP generated by a seed-growth method were spherical with diameters of ∼15 nm. Including palmitoyl-oleoyl-phosphatidylglycerol appeared to coat the NP with at least one lipid bilayer but did not affect NP shape or size. Similar overall observations occurred with dimyristoyl phosphatidylglycerol. Dipalmitoyl-phosphatidylglycerol was less effective in NP capping, although similar sized NP were formed. Including SP-B (1% wt/wt) appears to induce the formation of elongated strands of interacting threads with the fluid phosphatidylglycerols (PG). Including DPPC resulted in formation of aggregated, less spherical NP with a larger size distribution. With DPPC, strand formation due to SP-B was not observed. Agarose gel electrophoresis studies demonstrated that the aggregation induced by SP-B blocked migration of PG-coated NP. Migration was also influenced by the fluidity of the PGs. It is concluded that Au NP can interact with and sequester pulmonary surfactant phospholipids and, if inhaled from the atmosphere, could impede pulmonary surfactant function in the lung." @default.
- W2023193778 created "2016-06-24" @default.
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- W2023193778 date "2008-02-01" @default.
- W2023193778 modified "2023-10-15" @default.
- W2023193778 title "Metal Nanoparticle Pollutants Interfere with Pulmonary Surfactant Function In Vitro" @default.
- W2023193778 cites W1519065927 @default.
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- W2023193778 cites W185214452 @default.
- W2023193778 cites W1965238887 @default.
- W2023193778 cites W1965404488 @default.
- W2023193778 cites W1970900565 @default.
- W2023193778 cites W1971591693 @default.
- W2023193778 cites W1975102894 @default.
- W2023193778 cites W1975969810 @default.
- W2023193778 cites W1977166324 @default.
- W2023193778 cites W1977340812 @default.
- W2023193778 cites W1978926999 @default.
- W2023193778 cites W1984225260 @default.
- W2023193778 cites W1999931890 @default.
- W2023193778 cites W2002816181 @default.
- W2023193778 cites W2003186744 @default.
- W2023193778 cites W2011051154 @default.
- W2023193778 cites W2014636554 @default.
- W2023193778 cites W2014811196 @default.
- W2023193778 cites W2016363934 @default.
- W2023193778 cites W2022014262 @default.
- W2023193778 cites W2022696602 @default.
- W2023193778 cites W2024667807 @default.
- W2023193778 cites W2024816598 @default.
- W2023193778 cites W2025095419 @default.
- W2023193778 cites W2028250245 @default.
- W2023193778 cites W2029239015 @default.
- W2023193778 cites W2034829647 @default.
- W2023193778 cites W2035386775 @default.
- W2023193778 cites W2043414638 @default.
- W2023193778 cites W2044079201 @default.
- W2023193778 cites W2050786348 @default.
- W2023193778 cites W2059713268 @default.
- W2023193778 cites W2066633485 @default.
- W2023193778 cites W2072536943 @default.
- W2023193778 cites W2074190785 @default.
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- W2023193778 cites W2076849967 @default.
- W2023193778 cites W2082293149 @default.
- W2023193778 cites W2089068828 @default.
- W2023193778 cites W2089109996 @default.
- W2023193778 cites W2089931887 @default.
- W2023193778 cites W2091181311 @default.
- W2023193778 cites W2099253666 @default.
- W2023193778 cites W2101705789 @default.
- W2023193778 cites W2124988515 @default.
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- W2023193778 cites W2135996613 @default.
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- W2023193778 cites W2149097388 @default.
- W2023193778 cites W2149238866 @default.
- W2023193778 cites W2151945819 @default.
- W2023193778 cites W2153992927 @default.
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- W2023193778 cites W2160542981 @default.
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- W2023193778 cites W2169781816 @default.
- W2023193778 cites W2189334086 @default.
- W2023193778 cites W2269700608 @default.
- W2023193778 cites W2333888486 @default.
- W2023193778 cites W2396098363 @default.
- W2023193778 cites W2397303442 @default.
- W2023193778 cites W2398762604 @default.
- W2023193778 cites W2416262024 @default.
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- W2023193778 doi "https://doi.org/10.1529/biophysj.107.106971" @default.
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