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- W2023195079 abstract "Summary We studied the role of extra-and intracellular Ca2+ in endothelin-1 -induced contractions of the isolated human internal mammary artery and vein. Veins were more sensitive to the peptide than arteries (concentration shift: 3.2-fold; n = 4–10, p < 0.05). The Ca2+ antagonists darodipine, verapamil, and diltiazem (10-7-10-6M) did not prevent the response to endothelin-1 in both vessels. In contrast, darodipine (10-8 −10-6M), added after the contraction had developed, partially reversed the response in the artery (26 ± 7%) and particularly in the vein (67 ± 5%; n = 4, p < 0.005 compared to the artery). Removal of extracellular Ca2+ reduced the contractions to endothelin-1 (10-8M) in the artery (control: 89 ± 4% of 100 m M KCl; Ca2+ -free: 68 ± 4% n = 4–6, p < 0.01), but not in the vein except at low concentrations (10-9M) of the peptide. After removal of intracellular Ca2+ with caffeine in the artery, endothelin-1 still evoked a contraction (17 ± 3%, n = 3; p < 0.005 vs. control), while in the vein the response was abolished. Thus, mobilization of Ca2+ during endothelin-1-induced contractions differs in the human internal mammary artery and vein. In the artery, the contraction depends on extracellular Ca2+, intracellular caffeine-sensitive Ca2+ stores, and a caffeine-insensitive component, while in veins, mobilization of intracellular Ca2+ is most important. Ca2+ antagonists do not prevent, but partially reverse, endothelin-1-induced contractions indicating that voltage-operated Ca2+ channels do not initiate but contribute to the maintenance of the response." @default.
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- W2023195079 date "1990-10-01" @default.
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- W2023195079 title "Different Mobilization of Calcium in Endothelin-1 -Induced Contractions in Human Arteries and Veins: Effects of Calcium Antagonists" @default.
- W2023195079 doi "https://doi.org/10.1097/00005344-199010000-00019" @default.
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