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- W2023195892 abstract "Transforming growth factor-β (TGF-β) is a multifunctional cytokine that plays an important role in the regulation of cell growth, differentiation, apoptosis, and extracellular matrix production in a variety of cell types [1]. In the skin, abundant expression of three mammalian isoforms of TGF-βs (TGF-β1, -β2, -β3) are demonstrated at mRNA and protein levels in human epidermis by using in situ hybridization technique or immunohistochemistry [2–4] and it has been implicated in growth regulation of keratinocytes based on the evidence that (1) TGF-βs inhibit proliferation of normal human keratinocytes in vitro [5] and (2) transgenic mice that overexpress dominant negative TGF-β type II receptor in the epidermis show hyperplastic epidermis with increased BrdU uptake in basal and suprabasal keratinocytes [6]." @default.
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- W2023195892 date "2004-02-01" @default.
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- W2023195892 title "Expression of phosphorylated Smad2 in normal human epidermis" @default.
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- W2023195892 doi "https://doi.org/10.1016/j.jdermsci.2003.10.004" @default.
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