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- W2023196227 abstract "1 The N6-2-O-dibutyryl derivative of adenosine 3',5'-monophosphate (db cyclic AMP) has been micro-injected into the third cerebral ventricle of the unanaesthetized, restrained mouse and the effects on body temperature and thermoregulatory activities observed. 2 Db cyclic AMP (4, 16 and 32 micrograms) injected intracerebroventricularly produced hypothermia when compared with temperature responses to sodium n-butyrate (6.8 micrograms). 3 Hypothermia induced by db cyclic AMP in mice was associated with a fall in oxygen consumption together with behavioural and autonomic heat loss activities but not cutaneous vasodilatation. The effects on rectal temperature and oxygen consumption were dose-dependent. 4 The falls in rectal temperature and oxygen consumption induced by db cyclic AMP (4 micrograms) were decreased by elevation of the environmental temperature from 22 to 32 degrees C and abolished at 36 degrees C. 5 It is concluded db cyclic AMP may inhibit central events mediating the rise in metabolic heat production in mice upon exposure to cold environments." @default.
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- W2023196227 date "1980-11-01" @default.
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- W2023196227 title "THERMOREGULATORY EFFECTS OF N6-2′-O-DIBUTYRYL ADENOSINE 3′,5′-MONOPHOSPHATE IN THE RESTRAINED MOUSE" @default.
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- W2023196227 doi "https://doi.org/10.1111/j.1476-5381.1980.tb08723.x" @default.
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