FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2023197701> ?p ?o ?g. }

• W2023197701 endingPage "233" @default.
• W2023197701 startingPage "225" @default.
• W2023197701 abstract "The ability of amosite asbestos fibers to induce chromosomal aberrations in human primary mesothelial cells obtained from pleural effusions of 10 noncancerous patients was investigated. The glutathione S-transferase M1 (GSTM1) genotypes of the patients were determined, since the GSTM1 null genotype has been associated with increased susceptibility to lung cancer and chemically induced cytogenetic damage. Four of the patients represented the GSTM1 null genotype, and six the GSTM1 positive genotype. Successful chromosome aberration analyses were obtained from six cases, three of them with the GSTM1 null genotype. The level of aberrant cells in unexposed cultures ranged from 2.0% to 7.5%. Statistically significant increases (2.3-3.0-fold compared to controls) in the number of aberrant cells were observed in two cases only: in one case treated with 1 microgram/cm2 of amosite, and in another treated with 2 micrograms/cm2 of amosite. Cell cultures from four individuals showed minor or no increases in the numbers of aberrant cells in the doses tested (1 and 2 micrograms/cm2). Chromosome breaks were the major type of aberration. The amosite exposed cells with significantly increased aberrations were from patients with GSTM1 positive genotypes. Two cases that showed no cytogenetic response to asbestos fibers were of the GSTM1 null genotype. Thus, our results suggest that the lack of the GSTM1 gene does not render human mesothelial cells more susceptible to chromosomal damage induced by asbestos. GSTM1 null cells appeared, however, to be more sensitive to the growth inhibitory effects of asbestos than did GSTM1 positive cells. Variation in the cytogenetic response of human primary mesothelial cells to asbestos fibers was observed to exist, but the fibers do not appear to be potent inducers of structural chromosomal aberrations in these cells. It remains to be established whether individual sensitivity to asbestos fibers, due to specific genetic traits, exists." @default.
• W2023197701 created "2016-06-24" @default.
• W2023197701 creator A5023499634 @default.
• W2023197701 creator A5069636496 @default.
• W2023197701 creator A5078597245 @default.
• W2023197701 creator A5084900158 @default.
• W2023197701 date "1995-04-01" @default.
• W2023197701 modified "2023-09-25" @default.
• W2023197701 title "Cytogenetic response to asbestos fibers in cultured human primary mesothelial cells from 10 different donors" @default.
• W2023197701 cites W1496425906 @default.
• W2023197701 cites W1571462101 @default.
• W2023197701 cites W1967196243 @default.
• W2023197701 cites W1987791430 @default.
• W2023197701 cites W1989331869 @default.
• W2023197701 cites W1990503829 @default.
• W2023197701 cites W2003847760 @default.
• W2023197701 cites W2003939815 @default.
• W2023197701 cites W2004143105 @default.
• W2023197701 cites W2012245350 @default.
• W2023197701 cites W2017047165 @default.
• W2023197701 cites W2025200753 @default.
• W2023197701 cites W2032522259 @default.
• W2023197701 cites W2034933587 @default.
• W2023197701 cites W2051381951 @default.
• W2023197701 cites W2053513015 @default.
• W2023197701 cites W2083561906 @default.
• W2023197701 cites W2087009328 @default.
• W2023197701 cites W2091535349 @default.
• W2023197701 cites W2092696026 @default.
• W2023197701 cites W2093823503 @default.
• W2023197701 cites W2094997059 @default.
• W2023197701 cites W2098876987 @default.
• W2023197701 cites W2106879734 @default.
• W2023197701 cites W2108919777 @default.
• W2023197701 cites W2324458793 @default.
• W2023197701 doi "https://doi.org/10.1016/0165-1161(95)90015-2" @default.
• W2023197701 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/7885376" @default.
• W2023197701 hasPublicationYear "1995" @default.
• W2023197701 type Work @default.
• W2023197701 sameAs 2023197701 @default.
• W2023197701 citedByCount "27" @default.
• W2023197701 countsByYear W20231977012012 @default.
• W2023197701 countsByYear W20231977012013 @default.
• W2023197701 countsByYear W20231977012014 @default.
• W2023197701 countsByYear W20231977012016 @default.
• W2023197701 countsByYear W20231977012020 @default.
• W2023197701 crossrefType "journal-article" @default.
• W2023197701 hasAuthorship W2023197701A5023499634 @default.
• W2023197701 hasAuthorship W2023197701A5069636496 @default.
• W2023197701 hasAuthorship W2023197701A5078597245 @default.
• W2023197701 hasAuthorship W2023197701A5084900158 @default.
• W2023197701 hasConcept C104317684 @default.
• W2023197701 hasConcept C121853132 @default.
• W2023197701 hasConcept C135763542 @default.
• W2023197701 hasConcept C142724271 @default.
• W2023197701 hasConcept C153911025 @default.
• W2023197701 hasConcept C16685009 @default.
• W2023197701 hasConcept C191897082 @default.
• W2023197701 hasConcept C192562407 @default.
• W2023197701 hasConcept C203014093 @default.
• W2023197701 hasConcept C2909640154 @default.
• W2023197701 hasConcept C2994296024 @default.
• W2023197701 hasConcept C30481170 @default.
• W2023197701 hasConcept C510490043 @default.
• W2023197701 hasConcept C54355233 @default.
• W2023197701 hasConcept C71924100 @default.
• W2023197701 hasConcept C86803240 @default.
• W2023197701 hasConceptScore W2023197701C104317684 @default.
• W2023197701 hasConceptScore W2023197701C121853132 @default.
• W2023197701 hasConceptScore W2023197701C135763542 @default.
• W2023197701 hasConceptScore W2023197701C142724271 @default.
• W2023197701 hasConceptScore W2023197701C153911025 @default.
• W2023197701 hasConceptScore W2023197701C16685009 @default.
• W2023197701 hasConceptScore W2023197701C191897082 @default.
• W2023197701 hasConceptScore W2023197701C192562407 @default.
• W2023197701 hasConceptScore W2023197701C203014093 @default.
• W2023197701 hasConceptScore W2023197701C2909640154 @default.
• W2023197701 hasConceptScore W2023197701C2994296024 @default.
• W2023197701 hasConceptScore W2023197701C30481170 @default.
• W2023197701 hasConceptScore W2023197701C510490043 @default.
• W2023197701 hasConceptScore W2023197701C54355233 @default.
• W2023197701 hasConceptScore W2023197701C71924100 @default.
• W2023197701 hasConceptScore W2023197701C86803240 @default.
• W2023197701 hasIssue "2" @default.
• W2023197701 hasLocation W20231977011 @default.
• W2023197701 hasLocation W20231977012 @default.
• W2023197701 hasOpenAccess W2023197701 @default.
• W2023197701 hasPrimaryLocation W20231977011 @default.
• W2023197701 hasRelatedWork W1950674835 @default.
• W2023197701 hasRelatedWork W2023197701 @default.
• W2023197701 hasRelatedWork W2024877296 @default.
• W2023197701 hasRelatedWork W2043651529 @default.
• W2023197701 hasRelatedWork W2292416779 @default.
• W2023197701 hasRelatedWork W2408848550 @default.
• W2023197701 hasRelatedWork W2570474268 @default.
• W2023197701 hasRelatedWork W2955275382 @default.
• W2023197701 hasRelatedWork W1971946447 @default.
• W2023197701 hasRelatedWork W2077905626 @default.

• next