Matches in SemOpenAlex for { <https://semopenalex.org/work/W2023198045> ?p ?o ?g. }
- W2023198045 endingPage "202" @default.
- W2023198045 startingPage "195" @default.
- W2023198045 abstract "Eryptosis is a physiological phenomenon in which old and damaged erythrocytes are removed from circulation. Erythrocytes incubated with lead have exhibited major eryptosis. In the present work we found evidence of high levels of eryptosis in lead exposed workers possibly via oxidation. Blood samples were taken from 40 male workers exposed to lead (mean blood lead concentration 64.8μg/dl) and non-exposed workers (4.2μg/dl). The exposure to lead produced an intoxication characterized by 88.3% less δ-aminolevulinic acid dehydratase (δALAD) activity in lead exposed workers with respect to non-lead exposed workers. An increment of oxidation in lead exposed workers was characterized by 2.4 times higher thiobarbituric acid-reactive substance (TBARS) concentration and 32.8% lower reduced/oxidized glutathione (GSH/GSSG) ratio. Oxidative stress in erythrocytes of lead exposed workers is expressed in 192% higher free calcium concentration [Ca(2+)]i and 1.6 times higher μ-calpain activity with respect to non-lead exposed workers. The adenosine triphosphate (ATP) concentration was not significantly different between the two worker groups. No externalization of phosphatidylserine (PS) was found in non-lead exposed workers (<0.1%), but lead exposed workers showed 2.82% externalization. Lead intoxication induces eryptosis possibly through a molecular pathway that includes oxidation, depletion of reduced glutathione (GSH), increment of [Ca(2+)], μ-calpain activation and externalization of PS in erythrocytes. Identifying molecular signals that induce eryptosis in lead intoxication is necessary to understand its physiopathology and chronic complications." @default.
- W2023198045 created "2016-06-24" @default.
- W2023198045 creator A5011159714 @default.
- W2023198045 creator A5013141828 @default.
- W2023198045 creator A5036381714 @default.
- W2023198045 creator A5044243397 @default.
- W2023198045 creator A5051013871 @default.
- W2023198045 creator A5056275008 @default.
- W2023198045 date "2014-12-01" @default.
- W2023198045 modified "2023-10-18" @default.
- W2023198045 title "Eryptosis in lead-exposed workers" @default.
- W2023198045 cites W1556083772 @default.
- W2023198045 cites W18744606 @default.
- W2023198045 cites W1964138341 @default.
- W2023198045 cites W1965373426 @default.
- W2023198045 cites W1972050205 @default.
- W2023198045 cites W1979256466 @default.
- W2023198045 cites W1983418648 @default.
- W2023198045 cites W1984765893 @default.
- W2023198045 cites W1987240880 @default.
- W2023198045 cites W1997173552 @default.
- W2023198045 cites W2002178810 @default.
- W2023198045 cites W2002847421 @default.
- W2023198045 cites W2004140272 @default.
- W2023198045 cites W2006203283 @default.
- W2023198045 cites W2008354853 @default.
- W2023198045 cites W2008947055 @default.
- W2023198045 cites W2018335930 @default.
- W2023198045 cites W2018759424 @default.
- W2023198045 cites W2019471670 @default.
- W2023198045 cites W2025029173 @default.
- W2023198045 cites W2026551701 @default.
- W2023198045 cites W2028416085 @default.
- W2023198045 cites W2037211493 @default.
- W2023198045 cites W2043705396 @default.
- W2023198045 cites W2045461435 @default.
- W2023198045 cites W2045618968 @default.
- W2023198045 cites W2047276698 @default.
- W2023198045 cites W2047761142 @default.
- W2023198045 cites W2051215583 @default.
- W2023198045 cites W2053576249 @default.
- W2023198045 cites W2054786210 @default.
- W2023198045 cites W2057950182 @default.
- W2023198045 cites W2061902383 @default.
- W2023198045 cites W2064189043 @default.
- W2023198045 cites W2065196084 @default.
- W2023198045 cites W2066145167 @default.
- W2023198045 cites W2066978264 @default.
- W2023198045 cites W2070480173 @default.
- W2023198045 cites W2072409837 @default.
- W2023198045 cites W2073469813 @default.
- W2023198045 cites W2074702983 @default.
- W2023198045 cites W2076596458 @default.
- W2023198045 cites W2088565781 @default.
- W2023198045 cites W2097737947 @default.
- W2023198045 cites W2105749050 @default.
- W2023198045 cites W2106228333 @default.
- W2023198045 cites W2113053099 @default.
- W2023198045 cites W2116381459 @default.
- W2023198045 cites W2122881251 @default.
- W2023198045 cites W2124525373 @default.
- W2023198045 cites W2129335264 @default.
- W2023198045 cites W2131118500 @default.
- W2023198045 cites W2132225906 @default.
- W2023198045 cites W2132966139 @default.
- W2023198045 cites W2134192660 @default.
- W2023198045 cites W2136193967 @default.
- W2023198045 cites W2138011143 @default.
- W2023198045 cites W2139387137 @default.
- W2023198045 cites W2139953109 @default.
- W2023198045 cites W2146056429 @default.
- W2023198045 cites W2151699770 @default.
- W2023198045 cites W2152288875 @default.
- W2023198045 cites W2152379985 @default.
- W2023198045 cites W2157185335 @default.
- W2023198045 cites W2168500975 @default.
- W2023198045 cites W2266854094 @default.
- W2023198045 cites W2334570807 @default.
- W2023198045 cites W4248206010 @default.
- W2023198045 cites W4254094043 @default.
- W2023198045 doi "https://doi.org/10.1016/j.taap.2014.10.003" @default.
- W2023198045 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25448684" @default.
- W2023198045 hasPublicationYear "2014" @default.
- W2023198045 type Work @default.
- W2023198045 sameAs 2023198045 @default.
- W2023198045 citedByCount "24" @default.
- W2023198045 countsByYear W20231980452015 @default.
- W2023198045 countsByYear W20231980452016 @default.
- W2023198045 countsByYear W20231980452017 @default.
- W2023198045 countsByYear W20231980452018 @default.
- W2023198045 countsByYear W20231980452019 @default.
- W2023198045 countsByYear W20231980452020 @default.
- W2023198045 countsByYear W20231980452021 @default.
- W2023198045 countsByYear W20231980452022 @default.
- W2023198045 countsByYear W20231980452023 @default.
- W2023198045 crossrefType "journal-article" @default.
- W2023198045 hasAuthorship W2023198045A5011159714 @default.
- W2023198045 hasAuthorship W2023198045A5013141828 @default.