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Matches in SemOpenAlex for { <https://semopenalex.org/work/W2023199736> ?p ?o ?g. }

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• W2023199736 abstract "The synthesis of a novel series of 1,4-dihydropyrazolo[4,3-d]imidazole phenyl derivatives 1a–b, 2a–v and their antiproliferative activities against A375P and WM3629 human melanoma cell line were described. Most compounds showed competitive antiproliferative activities to sorafenib, the reference standard. Among them, pyrazoloimidazole phenyl urea compounds 2a, 2d, 2g, 2i, 2t exhibited potent activities on WM3629 cell lines (IC50 = 0.56–0.86 μM). Especially, 2t was found to be a potent and selective C-Raf inhibitor, showing a possibility as melanoma therapeutics." @default.
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• W2023199736 date "2010-06-01" @default.
• W2023199736 modified "2023-10-16" @default.
• W2023199736 title "1,4-Dihydropyrazolo[4,3-d]imidazole phenyl derivatives: A novel type II Raf kinase inhibitors" @default.
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• W2023199736 doi "https://doi.org/10.1016/j.bmcl.2010.04.039" @default.
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