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- W2023199771 abstract "The pharmacological action of the hydrazine analogue of phenylalanine is less than that of aliphatic amino acids and also shows decreased chronic toxicity while the acute toxicity is the same. As a carbonyl reagent NH-phenylalanine like other NH-amino acids reacts in vitro to form a hydrozane. Pyridoxal-5-phosphate dependent enzymes are inhibited at 10 times lower concentration by the hydrazine analogue and this inhibition can be prevented by adding the co-enzyme. In vivo enzymes in the brain are not inhibited while those of the liver are. The compound does not reduce blood pressure nor are any of its pharmacological actions dependent on optical activity." @default.
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- W2023199771 date "1965-08-01" @default.
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- W2023199771 title "Untersuchungen zum wirkungsmechanismus einer aromatischen hydrazinokarbonsäure, der β-phenyl-α-hydrazinopropionsäure" @default.
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- W2023199771 doi "https://doi.org/10.1016/0006-2952(65)90297-2" @default.
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