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• W2023199789 abstract "<h2>Abstract</h2> We investigated alterations in a β-adrenoceptor (BAR) system after reperfusion following hypothermic ischemia induced by a high-potassium (18 meq/liter) cardioplegic solution in isolated rat hearts. Materials were divided into two groups: the reperfusion group (Gr-R, <i>n</i> = 5) with 40 min reperfusion following 40 min cardioplegic arrest (10°C) and the control group (Gr-C, <i>n</i> = 5) with no ischemia as time-matched perfused control. BAR and adenylate cyclase activities in crude membrane fractions were compared. Results showed that basal, NaF-, and forskolin-stimulated adenylate cyclase activity did not differ between the two groups. The maximal enzyme activity in the presence of 10⁻⁴<i>M</i> (−)-isoproterenol was higher in Gr-R than in Gr-C, while the net activity stimulated by (−)-isoproterenol was 74% higher in Gr-R than in Gr-C. The [¹²⁵I]Iodocyanopindolol ([¹²⁵I]CYP) binding assay showed that BAR density was 14% higher in Gr-R than in Gr-C, while the affinity was not significantly different. The IC₅₀ values of (−)-isoproterenol for [¹²⁵I]CYP binding were lower in Gr-R than in Gr-C and the proportion of high-affinity binding sites was higher in Gr-R than in Gr-C. These data showed that 40 min reperfusion following hypothermic cardioplegic arrest (40 min) resulted in significant increases in myocardial BAR density and maximal (−)-isoproterenol-stimulated adenylate cyclase activity, and enhancement of BAR affinity for β-adrenergic agonists due to the increase in the proportion of high-affinity binding sites." @default.
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• W2023199789 date "1991-07-01" @default.
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• W2023199789 title "Enhancement of β-adrenoceptor function after reperfusion following cardioplegic arrest in rat hearts" @default.
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• W2023199789 doi "https://doi.org/10.1016/0022-4804(91)90073-u" @default.
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