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- W2023200100 abstract "A novel route for the efficient synthesis of a target psoralen moiety, 4,4′-dimethylxanthotoxol, has been developed, which need only four steps using cheap pyrogallol as a starting material. Subsequently, a range of new glycosylated psoralen derivatives were synthesized in good yields with simple procedures and mild reaction conditions. The experiment of biological activity shows that some of the glycosylated psoralen derivatives have antiproliferative activities against human cancer cell lines. A strong photo-induced antiproliferative effects were found under UVA. All of the glycosylated psoralen derivatives exhibited antioxidant activities against the oxidation of DNA induced by Cu2+/glutathione (GSH). Further experiment also demonstrates that the introduction of sugar moieties in some glycosylated psoralen derivatives can improve their antioxidant activities significantly." @default.
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- W2023200100 date "2012-03-01" @default.
- W2023200100 modified "2023-10-12" @default.
- W2023200100 title "Synthesis and biological evaluation of glycosylated psoralen derivatives" @default.
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- W2023200100 doi "https://doi.org/10.1016/j.tet.2012.01.090" @default.
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