Matches in SemOpenAlex for { <https://semopenalex.org/work/W2023200899> ?p ?o ?g. }
- W2023200899 endingPage "59" @default.
- W2023200899 startingPage "49" @default.
- W2023200899 abstract "All of the T cell receptor alpha- and beta-chain rearrangements present in a dual reactive T cell clone were characterized. This clone exhibits allelic exclusion of its beta-chain genes in that only one of the two alleles is productively rearranged. Unexpectedly, it displays two productive V alpha-gene rearrangements, which are both transcribed into 1.5 kb mRNA. The contribution of each of the two productive alpha genes to the dual recognition was analyzed by gene transfer. To this end, each of the two alpha genes was separately transfected with the single productively rearranged beta gene. Transfer of only one of the two alpha beta combinations restored both allogeneic MHC recognition and self MHC-restricted antigen recognition. Thus, T cell dual recognition results from the cross-reactive recognition of an allo-MHC product by a single antigen-specific and MHC-restricted alpha beta T cell receptor. Furthermore, the presence of two productively rearranged alpha-chain genes in a T cell clone raises questions concerning the level at which allelic exclusion operates in T cells." @default.
- W2023200899 created "2016-06-24" @default.
- W2023200899 creator A5003320334 @default.
- W2023200899 creator A5015033246 @default.
- W2023200899 creator A5018691327 @default.
- W2023200899 creator A5028288427 @default.
- W2023200899 creator A5029134288 @default.
- W2023200899 creator A5065142424 @default.
- W2023200899 creator A5066002524 @default.
- W2023200899 creator A5085306431 @default.
- W2023200899 date "1988-10-01" @default.
- W2023200899 modified "2023-10-18" @default.
- W2023200899 title "A T cell clone expresses two T cell receptor α genes but uses one αβ heterodimer for allorecognition and self MHC-restricted antigen recognition" @default.
- W2023200899 cites W1480489408 @default.
- W2023200899 cites W1558516755 @default.
- W2023200899 cites W1974280847 @default.
- W2023200899 cites W1982389510 @default.
- W2023200899 cites W1983302719 @default.
- W2023200899 cites W1986224986 @default.
- W2023200899 cites W1994127380 @default.
- W2023200899 cites W1994203213 @default.
- W2023200899 cites W1997056931 @default.
- W2023200899 cites W2004745504 @default.
- W2023200899 cites W2014718917 @default.
- W2023200899 cites W2024208188 @default.
- W2023200899 cites W202493911 @default.
- W2023200899 cites W2024943390 @default.
- W2023200899 cites W2027112152 @default.
- W2023200899 cites W2027807422 @default.
- W2023200899 cites W2033938686 @default.
- W2023200899 cites W2034211674 @default.
- W2023200899 cites W2034760746 @default.
- W2023200899 cites W2044305890 @default.
- W2023200899 cites W2047229372 @default.
- W2023200899 cites W2049596623 @default.
- W2023200899 cites W2054468433 @default.
- W2023200899 cites W2058809000 @default.
- W2023200899 cites W2062183507 @default.
- W2023200899 cites W2066347271 @default.
- W2023200899 cites W2066471533 @default.
- W2023200899 cites W2066913325 @default.
- W2023200899 cites W2070423612 @default.
- W2023200899 cites W2070818143 @default.
- W2023200899 cites W2080392270 @default.
- W2023200899 cites W2082919075 @default.
- W2023200899 cites W2089418619 @default.
- W2023200899 cites W2103788710 @default.
- W2023200899 cites W2107455919 @default.
- W2023200899 cites W2121447662 @default.
- W2023200899 cites W2144519616 @default.
- W2023200899 cites W2147731454 @default.
- W2023200899 cites W2149724286 @default.
- W2023200899 cites W2159760930 @default.
- W2023200899 cites W2173595496 @default.
- W2023200899 cites W2764324821 @default.
- W2023200899 cites W4294216491 @default.
- W2023200899 cites W4362040524 @default.
- W2023200899 doi "https://doi.org/10.1016/0092-8674(88)90008-6" @default.
- W2023200899 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/3262424" @default.
- W2023200899 hasPublicationYear "1988" @default.
- W2023200899 type Work @default.
- W2023200899 sameAs 2023200899 @default.
- W2023200899 citedByCount "189" @default.
- W2023200899 countsByYear W20232008992012 @default.
- W2023200899 countsByYear W20232008992013 @default.
- W2023200899 countsByYear W20232008992014 @default.
- W2023200899 countsByYear W20232008992015 @default.
- W2023200899 countsByYear W20232008992016 @default.
- W2023200899 countsByYear W20232008992019 @default.
- W2023200899 countsByYear W20232008992020 @default.
- W2023200899 countsByYear W20232008992021 @default.
- W2023200899 countsByYear W20232008992022 @default.
- W2023200899 countsByYear W20232008992023 @default.
- W2023200899 crossrefType "journal-article" @default.
- W2023200899 hasAuthorship W2023200899A5003320334 @default.
- W2023200899 hasAuthorship W2023200899A5015033246 @default.
- W2023200899 hasAuthorship W2023200899A5018691327 @default.
- W2023200899 hasAuthorship W2023200899A5028288427 @default.
- W2023200899 hasAuthorship W2023200899A5029134288 @default.
- W2023200899 hasAuthorship W2023200899A5065142424 @default.
- W2023200899 hasAuthorship W2023200899A5066002524 @default.
- W2023200899 hasAuthorship W2023200899A5085306431 @default.
- W2023200899 hasConcept C104317684 @default.
- W2023200899 hasConcept C147483822 @default.
- W2023200899 hasConcept C153911025 @default.
- W2023200899 hasConcept C19317047 @default.
- W2023200899 hasConcept C200315206 @default.
- W2023200899 hasConcept C207936829 @default.
- W2023200899 hasConcept C2776090121 @default.
- W2023200899 hasConcept C2778794311 @default.
- W2023200899 hasConcept C54355233 @default.
- W2023200899 hasConcept C81089528 @default.
- W2023200899 hasConcept C86803240 @default.
- W2023200899 hasConcept C8891405 @default.
- W2023200899 hasConceptScore W2023200899C104317684 @default.
- W2023200899 hasConceptScore W2023200899C147483822 @default.
- W2023200899 hasConceptScore W2023200899C153911025 @default.
- W2023200899 hasConceptScore W2023200899C19317047 @default.