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• W2023201113 abstract "Intermediate filaments (IFs) have recently been shown to serve novel roles during infection by many viruses. Here we have begun to study the role of IFs during the early steps of infection by the parvovirus minute virus of mice (MVM). We found that during early infection with MVM, after endosomal escape, the vimentin IF network was considerably altered, yielding collapsed immunofluorescence staining near the nuclear periphery. Furthermore, we found that vimentin plays an important role in the life cycle of MVM. The number of cells, which successfully replicated MVM, was reduced in infected cells in which the vimentin network was genetically or pharmacologically modified; viral endocytosis, however, remained unaltered. Perinuclear accumulation of MVM-containing vesicles was reduced in cells lacking vimentin. Our data suggests that vimentin is required for the MVM life cycle, presenting possibly a dual role: (1) following MVM escape from endosomes and (2) during endosomal trafficking of MVM." @default.
• W2023201113 created "2016-06-24" @default.
• W2023201113 creator A5041120830 @default.
• W2023201113 creator A5090337010 @default.
• W2023201113 date "2013-09-01" @default.
• W2023201113 modified "2023-09-25" @default.
• W2023201113 title "The intermediate filament network protein, vimentin, is required for parvoviral infection" @default.
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• W2023201113 doi "https://doi.org/10.1016/j.virol.2013.06.009" @default.
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