FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2023201368> ?p ?o ?g. }

• W2023201368 endingPage "187" @default.
• W2023201368 startingPage "177" @default.
• W2023201368 abstract "On the basis of conformational analysis of the vitamin D side chain and studies using conformationally restricted synthetic vitamin D analogs, we have suggested the active space region concept of vitamin D: The vitamin D side-chain region was grouped into four regions (A, G, EA and EG) and the A and EA regions were suggested to be important for vitamin D actions. We extended our theory to known highly potent vitamin D analogs and found a new region F. The analogs which occupy the F region have such modifications as 22-oxa, 22-ene, 16-ene and 18-nor. Altogether, the following relationship between the space region and activity was found: Affinity for vitamin D receptor (VDR), EA > A> F > G > EG; Affinity for vitamin D binding protein (DBP), A >> G,EA,EG; Target gene transactivation, EA > F > A > EG > or = G; Cell differentiation, EA > F > A > EG > or = G; Bone calcium mobilization, EA > GA > F > or = EG; Intestinal calcium absorption, EA = A > or = G >> EG. We modeled the 3D structure of VDR-LBD (ligand binding domain) using hRARgamma as a template, to develop our structure-function theory into a theory involving VDR. 1alpha,25(OH)(2)D(3) was docked into the ligand binding pocket of the VDR with the side chain heading the wide cavity at the H-11 site, the A-ring toward the narrow beta-turn site, and the beta-face of the CD ring facing H3. Amino acid residues forming hydrogen bonds with the 1alpha- and 25-OH groups were specified: S237 and R274 forming a pincer type hydrogen-bond for the 1alpha-OH and H397 for the 25-OH. Mutants of several amino acid residues that are hydrogen-bond candidates were prepared and their biologic properties were evaluated. All of our mutation results together with known mutation data support our VDR model docked with the natural ligand." @default.
• W2023201368 created "2016-06-24" @default.
• W2023201368 creator A5025564051 @default.
• W2023201368 creator A5027108774 @default.
• W2023201368 creator A5040084597 @default.
• W2023201368 creator A5060824665 @default.
• W2023201368 date "2001-03-01" @default.
• W2023201368 modified "2023-10-17" @default.
• W2023201368 title "Three-dimensional structure-function relationship of vitamin D and vitamin D receptor model" @default.
• W2023201368 cites W1526813480 @default.
• W2023201368 cites W1545280767 @default.
• W2023201368 cites W1552311020 @default.
• W2023201368 cites W1907321242 @default.
• W2023201368 cites W1971786066 @default.
• W2023201368 cites W1979136542 @default.
• W2023201368 cites W1991264023 @default.
• W2023201368 cites W1995247566 @default.
• W2023201368 cites W2000935329 @default.
• W2023201368 cites W2013252828 @default.
• W2023201368 cites W2013431059 @default.
• W2023201368 cites W2014967781 @default.
• W2023201368 cites W2039903367 @default.
• W2023201368 cites W2048146915 @default.
• W2023201368 cites W2052032176 @default.
• W2023201368 cites W2066229050 @default.
• W2023201368 cites W2073956186 @default.
• W2023201368 cites W2077420287 @default.
• W2023201368 cites W2080268456 @default.
• W2023201368 cites W2080978409 @default.
• W2023201368 cites W2081103930 @default.
• W2023201368 cites W2081984379 @default.
• W2023201368 cites W2090622441 @default.
• W2023201368 cites W2100493516 @default.
• W2023201368 cites W2101738855 @default.
• W2023201368 cites W2111650618 @default.
• W2023201368 cites W2116474322 @default.
• W2023201368 cites W2141662437 @default.
• W2023201368 cites W2165551557 @default.
• W2023201368 cites W2172256092 @default.
• W2023201368 cites W2329901146 @default.
• W2023201368 cites W2335617379 @default.
• W2023201368 cites W2412245931 @default.
• W2023201368 cites W248352688 @default.
• W2023201368 cites W2952111146 @default.
• W2023201368 cites W4248595930 @default.
• W2023201368 doi "https://doi.org/10.1016/s0039-128x(00)00145-8" @default.
• W2023201368 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11179725" @default.
• W2023201368 hasPublicationYear "2001" @default.
• W2023201368 type Work @default.
• W2023201368 sameAs 2023201368 @default.
• W2023201368 citedByCount "18" @default.
• W2023201368 countsByYear W20232013682012 @default.
• W2023201368 countsByYear W20232013682013 @default.
• W2023201368 crossrefType "journal-article" @default.
• W2023201368 hasAuthorship W2023201368A5025564051 @default.
• W2023201368 hasAuthorship W2023201368A5027108774 @default.
• W2023201368 hasAuthorship W2023201368A5040084597 @default.
• W2023201368 hasAuthorship W2023201368A5060824665 @default.
• W2023201368 hasConcept C104317684 @default.
• W2023201368 hasConcept C107824862 @default.
• W2023201368 hasConcept C112887158 @default.
• W2023201368 hasConcept C116569031 @default.
• W2023201368 hasConcept C124490489 @default.
• W2023201368 hasConcept C1292079 @default.
• W2023201368 hasConcept C134018914 @default.
• W2023201368 hasConcept C153639570 @default.
• W2023201368 hasConcept C170493617 @default.
• W2023201368 hasConcept C178790620 @default.
• W2023201368 hasConcept C179639408 @default.
• W2023201368 hasConcept C185592680 @default.
• W2023201368 hasConcept C204921945 @default.
• W2023201368 hasConcept C2776940978 @default.
• W2023201368 hasConcept C32909587 @default.
• W2023201368 hasConcept C521977710 @default.
• W2023201368 hasConcept C55493867 @default.
• W2023201368 hasConcept C71240020 @default.
• W2023201368 hasConcept C86339819 @default.
• W2023201368 hasConcept C86803240 @default.
• W2023201368 hasConceptScore W2023201368C104317684 @default.
• W2023201368 hasConceptScore W2023201368C107824862 @default.
• W2023201368 hasConceptScore W2023201368C112887158 @default.
• W2023201368 hasConceptScore W2023201368C116569031 @default.
• W2023201368 hasConceptScore W2023201368C124490489 @default.
• W2023201368 hasConceptScore W2023201368C1292079 @default.
• W2023201368 hasConceptScore W2023201368C134018914 @default.
• W2023201368 hasConceptScore W2023201368C153639570 @default.
• W2023201368 hasConceptScore W2023201368C170493617 @default.
• W2023201368 hasConceptScore W2023201368C178790620 @default.
• W2023201368 hasConceptScore W2023201368C179639408 @default.
• W2023201368 hasConceptScore W2023201368C185592680 @default.
• W2023201368 hasConceptScore W2023201368C204921945 @default.
• W2023201368 hasConceptScore W2023201368C2776940978 @default.
• W2023201368 hasConceptScore W2023201368C32909587 @default.
• W2023201368 hasConceptScore W2023201368C521977710 @default.
• W2023201368 hasConceptScore W2023201368C55493867 @default.
• W2023201368 hasConceptScore W2023201368C71240020 @default.
• W2023201368 hasConceptScore W2023201368C86339819 @default.
• W2023201368 hasConceptScore W2023201368C86803240 @default.

• next