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• W2023202239 endingPage "1638" @default.
• W2023202239 startingPage "1629" @default.
• W2023202239 abstract "Cluster immunotherapy represents an interesting alternative to conventional up-dosing schedules because it allows achieving the maintenance dose within a shorter time interval. In this study, the efficacy and safety of cluster immunotherapy with a high polymerized allergen extract of a grass/rye pollen mixture have been evaluated in a randomized, double-blind, placebo-controlled, multicenter study.In total, 121 patients with allergic rhinoconjunctivitis due to grass pollen were randomized 1 : 1 to verum or placebo group. A short cluster up-dosing schedule of only 1 week was applied to achieve the maintenance dose which was administered monthly during the study period of 1 year. Total combined symptom and medication score (TCS) was defined as primary outcome parameter. Secondary outcome parameters were individual symptom and medication scores, 'well days,' global improvement as well as immunological effects and nasal allergen challenge. The safety profile was evaluated based on the European academy of allergy and clinical immunology grading system.Significant reduction in the verum compared to the placebo group (intention-to-treat, population, verum: n = 55; placebo: n = 47) was found regarding TCS (P = 0.005), rhinoconjunctivitis total symptom score (RTSS, P = 0.006), and total rescue medication score (TRMS, P = 0.002). Additionally, secondary outcomes such as 'well days,' nasal challenge results, and increase of specific IgG4 were in favor of the active treatment. All systemic adverse reactions (0.8% of all injections in the verum group) were of mild intensity. No severe reactions related to the study medication were observed.Cluster immunotherapy with high polymerized grass pollen extracts resulted in significant clinical efficacy and has been shown to be a safe treatment for grass pollen-allergic patients." @default.
• W2023202239 created "2016-06-24" @default.
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• W2023202239 date "2014-10-06" @default.
• W2023202239 modified "2023-09-30" @default.
• W2023202239 title "A high polymerized grass pollen extract is efficacious and safe in a randomized double‐blind, placebo‐controlled study using a novel up‐dosing cluster‐protocol" @default.
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• W2023202239 doi "https://doi.org/10.1111/all.12513" @default.
• W2023202239 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4238814" @default.
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