Matches in SemOpenAlex for { <https://semopenalex.org/work/W2023202246> ?p ?o ?g. }
Showing items 1 to 84 of
84
with 100 items per page.
- W2023202246 abstract "The aim was to investigate HA as a potential contrast agent for first‐pass myocardial perfusion imaging*, and to assess the imaging performance of gadolinium‐hyaluronic acid (HA) polymer complexes from HA‐ligand constructs by determining the proton longitudinal relaxivities and accurate relaxation rates in saline solutions at 10.72 MHz. Imaging of same solutions in well defined dialysis tubing at 3T using a constructed phantom was then used to measure the rate of diffusion to determine if the Gd‐complex polymer conjugate would have a sufficiently large hydrodynamic size to prevent immediate perfusion through vascular wall‐like conditions to account for leaks from the intravascular to interstitial space. Samples denoted as HW02‐18 Sample A and HW02‐18 Sample B were successfully prepared by coupling an amine functionalized DTPA with HA via EDC/NHS coupling methods. These produced the highest relaxation rates and relaxivities at 10.72 MHz compared to the other preparation methods. Twenty four hours post‐injection, Gadodiamide showed a signal to noise ratio of unity, while HW‐147 continued to retain some degree of contrast relative to the background. The slope of the logarithmic fit corresponding to HW01‐147 was estimated at −0.006 compared to −0.01 of Gadodiamide, a much steeper drop indicating smaller molecular size and faster perfusion rate across the dialysis membranes. This is demonstrative of the Gd ion's relative freedom to influence the R1 of extracellular water molecules, while the molecular size of the Gd‐polymer complex has a molecular radius that is sufficiently large to prevent vascular‐like perfusion. This is a necessary prerequisite for HA bound Gd as a contrast agent for first‐pass myocardial perfusion imaging." @default.
- W2023202246 created "2016-06-24" @default.
- W2023202246 creator A5032156794 @default.
- W2023202246 creator A5036451016 @default.
- W2023202246 creator A5069076963 @default.
- W2023202246 date "2009-06-01" @default.
- W2023202246 modified "2023-09-23" @default.
- W2023202246 title "SU-FF-I-133: Assessing the Magnetic Resonance Imaging Performance of Gadolinium-Hyaluronic Acid Polymer Contrast Agents in Phosphate Buffered Saline" @default.
- W2023202246 doi "https://doi.org/10.1118/1.3181254" @default.
- W2023202246 hasPublicationYear "2009" @default.
- W2023202246 type Work @default.
- W2023202246 sameAs 2023202246 @default.
- W2023202246 citedByCount "0" @default.
- W2023202246 crossrefType "journal-article" @default.
- W2023202246 hasAuthorship W2023202246A5032156794 @default.
- W2023202246 hasAuthorship W2023202246A5036451016 @default.
- W2023202246 hasAuthorship W2023202246A5069076963 @default.
- W2023202246 hasConcept C121332964 @default.
- W2023202246 hasConcept C126838900 @default.
- W2023202246 hasConcept C136229726 @default.
- W2023202246 hasConcept C136339569 @default.
- W2023202246 hasConcept C143409427 @default.
- W2023202246 hasConcept C150903083 @default.
- W2023202246 hasConcept C159985019 @default.
- W2023202246 hasConcept C185592680 @default.
- W2023202246 hasConcept C191897082 @default.
- W2023202246 hasConcept C192562407 @default.
- W2023202246 hasConcept C207001950 @default.
- W2023202246 hasConcept C2780026267 @default.
- W2023202246 hasConcept C28396438 @default.
- W2023202246 hasConcept C46141821 @default.
- W2023202246 hasConcept C521977710 @default.
- W2023202246 hasConcept C557651011 @default.
- W2023202246 hasConcept C71924100 @default.
- W2023202246 hasConcept C73286259 @default.
- W2023202246 hasConcept C83042744 @default.
- W2023202246 hasConcept C86803240 @default.
- W2023202246 hasConceptScore W2023202246C121332964 @default.
- W2023202246 hasConceptScore W2023202246C126838900 @default.
- W2023202246 hasConceptScore W2023202246C136229726 @default.
- W2023202246 hasConceptScore W2023202246C136339569 @default.
- W2023202246 hasConceptScore W2023202246C143409427 @default.
- W2023202246 hasConceptScore W2023202246C150903083 @default.
- W2023202246 hasConceptScore W2023202246C159985019 @default.
- W2023202246 hasConceptScore W2023202246C185592680 @default.
- W2023202246 hasConceptScore W2023202246C191897082 @default.
- W2023202246 hasConceptScore W2023202246C192562407 @default.
- W2023202246 hasConceptScore W2023202246C207001950 @default.
- W2023202246 hasConceptScore W2023202246C2780026267 @default.
- W2023202246 hasConceptScore W2023202246C28396438 @default.
- W2023202246 hasConceptScore W2023202246C46141821 @default.
- W2023202246 hasConceptScore W2023202246C521977710 @default.
- W2023202246 hasConceptScore W2023202246C557651011 @default.
- W2023202246 hasConceptScore W2023202246C71924100 @default.
- W2023202246 hasConceptScore W2023202246C73286259 @default.
- W2023202246 hasConceptScore W2023202246C83042744 @default.
- W2023202246 hasConceptScore W2023202246C86803240 @default.
- W2023202246 hasLocation W20232022461 @default.
- W2023202246 hasOpenAccess W2023202246 @default.
- W2023202246 hasPrimaryLocation W20232022461 @default.
- W2023202246 hasRelatedWork W1419379837 @default.
- W2023202246 hasRelatedWork W1543635496 @default.
- W2023202246 hasRelatedWork W1979927327 @default.
- W2023202246 hasRelatedWork W2005255119 @default.
- W2023202246 hasRelatedWork W2006308857 @default.
- W2023202246 hasRelatedWork W2008414669 @default.
- W2023202246 hasRelatedWork W2028051485 @default.
- W2023202246 hasRelatedWork W2031193647 @default.
- W2023202246 hasRelatedWork W2046174672 @default.
- W2023202246 hasRelatedWork W2055675489 @default.
- W2023202246 hasRelatedWork W2062971965 @default.
- W2023202246 hasRelatedWork W2063477883 @default.
- W2023202246 hasRelatedWork W2069680260 @default.
- W2023202246 hasRelatedWork W2116696774 @default.
- W2023202246 hasRelatedWork W2131067983 @default.
- W2023202246 hasRelatedWork W2134519745 @default.
- W2023202246 hasRelatedWork W2184571153 @default.
- W2023202246 hasRelatedWork W261578406 @default.
- W2023202246 hasRelatedWork W2187773918 @default.
- W2023202246 hasRelatedWork W2737337790 @default.
- W2023202246 isParatext "false" @default.
- W2023202246 isRetracted "false" @default.
- W2023202246 magId "2023202246" @default.
- W2023202246 workType "article" @default.